The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis

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dc.contributor.authorMeira, Domingos Alves [UNESP]
dc.contributor.authorPereira, Paulo Camara Marques [UNESP]
dc.contributor.authorMarcondes-Machado, Jussara [UNESP]
dc.contributor.authorMendes, Rinaldo Poncio [UNESP]
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.authorPellegrino Jr., Jordao
dc.contributor.authorRezkallah-Iwasso, Maria Tereza
dc.contributor.authorPeracoli, Maria Therezinha Serrao
dc.contributor.authorCastilho, Lilian Maria
dc.contributor.authorThomazini, Izolete
dc.contributor.authorSilva, Celio Lopes D.A.
dc.contributor.authorFoss, Norma Tiraboschi
dc.contributor.authorCuri, Paulo Roberto
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSecretaria de Saude do Estado de S.
dc.contributor.institutionInstituto de Biociencias
dc.contributor.institutionHemocentro de Botucatu
dc.contributor.institutionAvenida Bandeirantes No. 3900
dc.contributor.institutionFaculdade de Med. Vet. E Zootecnia
dc.date.accessioned2022-04-28T19:56:40Z
dc.date.available2022-04-28T19:56:40Z
dc.date.issued1996-01-01
dc.description.abstractA group of 10 patients, nine of them seriously infected with Paracoccidioides brasiliensis (G1), received glucan (beta-1,3 polyglucose) as an immunostimulant intravenously once a week for one month, followed by monthly doses (10 mg) over an 11-month period, together with a specific anti- fungal agent as an immunostimulant. A second group of eight moderately infected patients (G2) was treated with only the anti-fungal agent. Among the patients in G1, there was only one case of relapse compared with five in G2. Values for the erythrocyte sedimentation rate (ESR) showed a significant difference (P < 0.01) post-treatment in G1 patients, when compared with the pretreatment levels. There was also a significant reduction (P < 0.001) in the level of serum antibodies to P. brasiliensis in the G1 patients in post- treatment examinations. The phytohemagglutinin (PHA) skin test showed a positive reaction among the patients in G1 (P < 0.01) post-treatment and there was a tendency towards an increase in the number of CD4+ T lymphocytes in both groups after treatment. The serum level of tumor necrosis factor (TNF) proved to be significantly higher (P < 0.02) in the G1 patients during treatment. In the G1 patients, the correlation between ESR and TNF tended to be negative whereas that between ESR and serum antibodies was positive. The present results indicate that the patients who received glucan, in spite of being more seriously ill, had a stronger and more favorable response to therapy.en
dc.description.affiliationDepanamento de Doencas Tropicais E. Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo, 18618-000
dc.description.affiliationSecretaria de Saude do Estado de S., Rua Dr. Eneas de Carvalho, Sao Paulo, 05403-000
dc.description.affiliationDepartamento de Microbiologia Instituto de Biociencias, Botucatu, Sao Paulo, 18618-000
dc.description.affiliationHemocentro de Botucatu, Botucatu, Sao Paulo, 18618-000
dc.description.affiliationFaculdade de Med. de Ribeirao Preto Avenida Bandeirantes No. 3900 Campus Universitario, Ribeirao Preto, Sao Paulo, 04049-900
dc.description.affiliationFaculdade de Med. Vet. E Zootecnia, Botucatu, Sao Paulo, 18618-000
dc.description.affiliationDepartamento de Doencas Tropicais Faculdade de Medicina de Botucatu, Botucatu, PO Box 522, Sao Paulo, 18618-000
dc.description.affiliationUnespDepanamento de Doencas Tropicais E. Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo, 18618-000
dc.description.affiliationUnespDepartamento de Doencas Tropicais Faculdade de Medicina de Botucatu, Botucatu, PO Box 522, Sao Paulo, 18618-000
dc.format.extent496-503
dc.identifierhttp://dx.doi.org/10.4269/ajtmh.1996.55.496
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene, v. 55, n. 5, p. 496-503, 1996.
dc.identifier.doi10.4269/ajtmh.1996.55.496
dc.identifier.issn0002-9637
dc.identifier.scopus2-s2.0-10544224534
dc.identifier.urihttp://hdl.handle.net/11449/224473
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.sourceScopus
dc.titleThe use of glucan as immunostimulant in the treatment of paracoccidioidomycosisen
dc.typeArtigo

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