Radioprotection of beta-carotene evaluated on mouse somatic and germ cells

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dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorRibeiro, Lúcia Regina [UNESP]
dc.contributor.authorXiao, Y.
dc.contributor.authorBoei, J. J.
dc.contributor.authorNatarajan, A. T.
dc.contributor.institutionLEIDEN STATE UNIV
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:59Z
dc.date.available2014-05-20T15:27:59Z
dc.date.issued1996-09-23
dc.description.abstractIn the present paper, the protective effect of beta-carotene was evaluated after whole body exposure of mice to 2 Gy of X-rays. Splenocytes, reticulocytes, bone marrow cells and spermatids were evaluated for the frequency of micronuclei (MN) induced by X-rays. Mice were treated (gavage) with beta-carotene (10, 25 and 50 mg/kg b.w.) for 5 consecutive days and, 4 h after the last treatment, the animals were irradiated. The results obtained showed different frequencies of X-ray-induced-MN between different cell populations analysed and also different response of these cells to the beta-carotene treatment. The radioprotective effect of beta-carotene was observed in splenocytes, reticulocytes, and spermatids but not in bone marrow cells. No dose-response relationship for beta-carotene was detected. The time of sampling, the sensitivity of the cells as well as the antioxidant activity of beta-carotene are discussed as important factors for the radioprotective action of this provitamin.en
dc.description.affiliationLEIDEN STATE UNIV,SYLVIUS LAB,MGC DEPT RADIAT GENET & CHEM MUTAGENESIS,NL-2333 AL LEIDEN,NETHERLANDS
dc.format.extent163-170
dc.identifierhttp://dx.doi.org/10.1016/0027-5107(96)00040-1
dc.identifier.citationMutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 356, n. 2, p. 163-170, 1996.
dc.identifier.doi10.1016/0027-5107(96)00040-1
dc.identifier.issn0027-5107
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/37895
dc.identifier.wosWOS:A1996VJ55900005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
dc.relation.ispartofjcr2.398
dc.relation.ispartofsjr0,111
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbeta-carotenept
dc.subjectradioprotectorspt
dc.subjectantimutagenicitypt
dc.subjectmicronucleuspt
dc.titleRadioprotection of beta-carotene evaluated on mouse somatic and germ cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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