Race for Applicable Antimicrobial Dental Implant Surfaces to Fight Biofilm-Related Disease: Advancing in Laboratorial Studies vs Stagnation in Clinical Application

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dc.contributor.authorDe Avila, Erica D. [UNESP]
dc.contributor.authorNagay, Bruna E.
dc.contributor.authorPereira, Marta M. A. [UNESP]
dc.contributor.authorBarão, Valentim A. R.
dc.contributor.authorPavarina, Ana Claudia [UNESP]
dc.contributor.authorVan Den Beucken, Jeroen J. J. P.
dc.contributor.institutionGuarulhos University (UNG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionRadboudumc
dc.date.accessioned2023-03-01T21:05:16Z
dc.date.available2023-03-01T21:05:16Z
dc.date.issued2022-08-08
dc.description.abstractAcross years, potential strategies to fight peri-implantitis have been notoriously explored through the antimicrobial coating implant surfaces capable of interfering with the bacterial adhesion process. However, although experimental studies have significantly advanced, no product has been marketed so far. For science to reach the society, the commercialization of research outcomes is necessary to provide real advancement in the biomedical field. Therefore, the aim of this study was to investigate the challenges involved in the development of antimicrobial dental implant surfaces to fight peri-implantitis, through a systematic search. Research articles reporting antimicrobial dental implant surfaces were identified by searching PubMed, Scopus, Web of Science, The Cochrane Library, Embase, and System of Information on Grey Literature in Europe, between 2008 and 2020. A total of 1778 studies were included for quality assessment and the review. An impressive number of 1655 articles (93,1%) comprised in vitro studies, whereas 123 articles refer to in vivo investigations. From those 123, 102 refer to animal studies and only 21 articles were published on the clinical performance of antibacterial dental implant surfaces. The purpose of animal studies is to test how safe and effective new treatments are before they are tested in people. Therefore, the discrepancy between the number of published studies clearly reveals that preclinical investigations still come up against several challenges to overcome before moving forward to a clinical setting. Additionally, researchers need to recognize that the complex journey from lab to market requires more than a great idea and resources to develop a commercial invention; research teams must possess the skills necessary to commercialize an invention.en
dc.description.affiliationDental Research Division Guarulhos University (UNG), Praça Tereza Cristina, 88 - Centro, São Paulo
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry at Araraquara Sao Paulo State University (UNESP), Rua Humaita, 1680, São Paulo
dc.description.affiliationDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), Av. Limeira, 901, São Paulo
dc.description.affiliationRegenerative Biomaterials Radboudumc, Philips Van Leydenlaan 25
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry at Araraquara Sao Paulo State University (UNESP), Rua Humaita, 1680, São Paulo
dc.format.extent3187-3198
dc.identifierhttp://dx.doi.org/10.1021/acsbiomaterials.2c00160
dc.identifier.citationACS Biomaterials Science and Engineering, v. 8, n. 8, p. 3187-3198, 2022.
dc.identifier.doi10.1021/acsbiomaterials.2c00160
dc.identifier.issn2373-9878
dc.identifier.scopus2-s2.0-85135599409
dc.identifier.urihttp://hdl.handle.net/11449/241482
dc.language.isoeng
dc.relation.ispartofACS Biomaterials Science and Engineering
dc.sourceScopus
dc.subjectanti-infective agents
dc.subjectdental implants
dc.subjectsurface treatment
dc.titleRace for Applicable Antimicrobial Dental Implant Surfaces to Fight Biofilm-Related Disease: Advancing in Laboratorial Studies vs Stagnation in Clinical Applicationen
dc.typeResenha
unesp.author.orcid0000-0001-6681-1269 0000-0001-6681-1269[1]
unesp.author.orcid0000-0002-4927-0779[2]
unesp.author.orcid0000-0002-6391-9917[4]
unesp.author.orcid0000-0002-0301-1966[6]

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