Laser 904 nm action on bone repair in rats with osteoporosis

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dc.contributor.authorPires-Oliveira, D. A. A.
dc.contributor.authorOliveira, R. F.
dc.contributor.authorAmadei, S. U.
dc.contributor.authorPacheco-Soares, C.
dc.contributor.authorRocha, R. F. [UNESP]
dc.contributor.institutionUniv Camilo Castelo Branco Unicastelo São Paulo
dc.contributor.institutionFac Pindamonhangaba Fapi
dc.contributor.institutionUnivap
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:18Z
dc.date.available2014-05-20T15:32:18Z
dc.date.issued2010-12-01
dc.description.abstractThe aim of the present study was to determine the action of AsGA laser irradiation on bone repair in the tibia of osteopenic rats. The animals were randomly divided into eight experimental groups according to the presence of ovarian hormone (sham group) or the absence of the hormone (OVX group), as well as being irradiated or non-irradiated. Low-level 904-nm laser (50 mJ/cm(2)) accelerated the repair process of osteopenic fractures, especially in the initial phase of bone regeneration.Introduction The development of new techniques to speed the process of bone repair has provided significant advances in the treatment of fractures. Some attention recently focused on the effects of biostimulation on bone.Methods Forty-eight adult rats were randomly divided into eight experimental groups (six animals in each group) according to the presence of ovarian hormone (sham group) or absence of the hormone (ovariectomized (OVX) group) as well as being irradiated or non-irradiated. For the application of low-level laser therapy, the animals were anesthetized with one third of the dose sufficient to immobilize the animal and irradiated with AsGa laser (904 nm, 50 mJ/cm(2) for 2s, point form and in contact). The control animals received the same type of manipulation as the irradiated animals, but with the laser turned off. Half of the animals were killed 7 days following the confection of the bone defect, and the other half were killed 21 days after the surgery. After complete demineralization, the tibias were cut cross-sectionally in the central region of the bone defect and embedded in paraffin blocks. The blocks were then cut in semi-seriated slices and stained with hematoxylin and eosin.Results There was new bone formation in the animals in the OVX group with laser treatment killed after 7 days (p<0.001). The lowest percentage of bone formation was observed in the OVX without laser killed after 7 days (p>0.05). All animals killed after 21 days exhibited linear closure of the lesion.Conclusion Low-level 904-nm laser (50 mJ/cm(2)) accelerated the repair process of osteopenic fractures, especially in the initial phase of bone regeneration.en
dc.description.affiliationUniv Camilo Castelo Branco Unicastelo São Paulo, Programa Posgrad Unicastelo, Dept Curso Odontol, BR-08230030 São Paulo, Brazil
dc.description.affiliationFac Pindamonhangaba Fapi, São Paulo, Brazil
dc.description.affiliationUnivap, IP&D, Lab Dinam Compartimentos Intracelular, Inst Pesquisa & Desenvolvimento, BR-12244000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Odontol Sao Jose Campos, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Biociencias & Diagnost Bucal, BR-12244090 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Odontol Sao Jose Campos, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Biociencias & Diagnost Bucal, BR-12244090 São Paulo, Brazil
dc.description.sponsorshipNelson Fuirini Junior, Brazil
dc.format.extent2109-2114
dc.identifierhttp://dx.doi.org/10.1007/s00198-010-1183-8
dc.identifier.citationOsteoporosis International. London: Springer London Ltd, v. 21, n. 12, p. 2109-2114, 2010.
dc.identifier.doi10.1007/s00198-010-1183-8
dc.identifier.issn0937-941X
dc.identifier.urihttp://hdl.handle.net/11449/41241
dc.identifier.wosWOS:000285306900016
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofOsteoporosis International
dc.relation.ispartofjcr3.856
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBone regenerationen
dc.subjectLow-level laser therapyen
dc.subjectOsteoporosisen
dc.subjectPhotobiomodulationen
dc.titleLaser 904 nm action on bone repair in rats with osteoporosisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer London Ltd
unesp.author.orcid0000-0002-0572-074X[4]

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