COVID-19 in chronic myeloid leukemia patients in Latin America

dc.contributor.authorPagnano, Katia B.
dc.contributor.authorPeralta, Evelyn Herrera
dc.contributor.authorNavarro, Juan Ramon
dc.contributor.authorDavid Salas, Lourdes del Rosario
dc.contributor.authorDelgado, Nancy
dc.contributor.authorMoiraghi, Beatriz
dc.contributor.authorToreli, Ana Carolina M.
dc.contributor.authorPerobelli, Leila M.
dc.contributor.authorFechio, Leonardo
dc.contributor.authorQuixada, Acy T. S.
dc.contributor.authorFunke, Vaneuza
dc.contributor.authorBendit, Israel
dc.contributor.authorSeguro, Fernanda S.
dc.contributor.authorPilleux, Lilian
dc.contributor.authorBortolini, Jaisson
dc.contributor.authorLourenço, André L. G.
dc.contributor.authorSapelli, Jaqueline
dc.contributor.authorNucci, Fabio M.
dc.contributor.authorPavlovsky, Carolina
dc.contributor.authorOliveira, Luciene Da Cruz
dc.contributor.authorMoura, Muriel Silva
dc.contributor.authorPalma, Leonardo C.
dc.contributor.authorGonçalves, Natalia N.
dc.contributor.authorConchon, Monika
dc.contributor.authorHokama, Paula O.M. [UNESP]
dc.contributor.authorAlmeida, Leandro Lustri [UNESP]
dc.contributor.authorZulli, Roberto
dc.contributor.authorde Souza, Carmino Antonio
dc.contributor.authorBoquimpani, Carla M.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionHospital Nacional Edgardo Rebagliati Martins
dc.contributor.institutionCentro Médico Nacional Siglo XXI IMSS
dc.contributor.institutionJM Ramos Mejia CABA
dc.contributor.institutionHospital de Transplantes Euryclides de Jesus Zerbini
dc.contributor.institutionHospital Universitário Walter Cantídio
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCentro de Pesquisas Oncológicas
dc.contributor.institutionHospital dos Fornecedores de Cana de Piracicaba
dc.contributor.institutionHospital AC Camargo Cancer Center
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionHospital Jorge Valente
dc.contributor.institutionHospital Santa Casa de Misericordia de Maceió
dc.contributor.institutionHospital Santa Marcelina
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.abstractThis observational, multicenter study aimed to report the clinical evolution of COVID-19 in patients with chronic myeloid leukemia in Latin America. A total of 92 patients presented with COVID-19 between March and December 2020, 26% of whom were severe or critical. The median age at COVID-19 diagnosis was 48 years (22–79 years), 32% were 60 years or older, and 61% were male. Thirty-nine patients presented with at least one comorbidity (42.3%). Eighty-one patients recovered (88%), and 11 (11.9%) died from COVID-19. There was one case of reinfection. Patients with a major molecular response presented superior overall survival compared to patients with no major molecular response (91 vs. 61%, respectively; p = 0.004). Patients in treatment-free remission and receiving tyrosine kinase inhibitors showed higher survival rates than patients who underwent hematopoietic stem cell transplantation and those who did not receive tyrosine kinase inhibitors (100, 89, 50, and 33%, respectively; p < 0.001).en
dc.description.affiliationHematology and Hemotherapy Center University of Campinas
dc.description.affiliationHospital Nacional Edgardo Rebagliati Martins
dc.description.affiliationCentro Médico Nacional Siglo XXI IMSS
dc.description.affiliationJM Ramos Mejia CABA
dc.description.affiliationHospital de Transplantes Euryclides de Jesus Zerbini
dc.description.affiliationFaculdade de Medicina da Universidade Federal do Ceará Hospital Universitário Walter Cantídio
dc.description.affiliationComplexo Hospital de Clínicas–Universidade Federal do Paraná
dc.description.affiliationLaboratory of Medical Investigation in Pathogenesis and targeted therapy in Onco-Immuno-Hematology (LIM/31) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
dc.description.affiliationHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
dc.description.affiliationHospital de Valdivia Bueras
dc.description.affiliationCentro de Pesquisas Oncológicas
dc.description.affiliationHospital dos Fornecedores de Cana de Piracicaba
dc.description.affiliationHospital AC Camargo Cancer Center
dc.description.affiliationHospital Universitário Antonio Pedro Universidade Federal Fluminense
dc.description.affiliationHospitalization & Clinical Research Center Fundaleu
dc.description.affiliationHospital Jorge Valente
dc.description.affiliationHospital Santa Casa de Misericordia de Maceió
dc.description.affiliationHospital das Clínicas da Faculdade de Medicina de Ribeirão Preto University of São Paulo
dc.description.affiliationHospital Santa Marcelina
dc.description.affiliationSão Paulo State University UNESP Medical School Campus de Botucatu
dc.description.affiliationUnespSão Paulo State University UNESP Medical School Campus de Botucatu
dc.identifier.citationLeukemia and Lymphoma.
dc.relation.ispartofLeukemia and Lymphoma
dc.subjectchronic myeloid leukemia
dc.subjectmolecular response
dc.titleCOVID-19 in chronic myeloid leukemia patients in Latin Americaen