Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

Página do item simplificado
dc.contributor.authorFrancisqueti-Ferron, Fabiane Valentini [UNESP]
dc.contributor.authorTogneri Ferron, Artur Junio [UNESP]
dc.contributor.authorGarcia, Jessica Leite [UNESP]
dc.contributor.authorVagula de Almeida Silva, Carol Cristina [UNESP]
dc.contributor.authorCosta, Mariane Rovero [UNESP]
dc.contributor.authorGregolin, Cristina Schmitt [UNESP]
dc.contributor.authorMoreto, Fernando [UNESP]
dc.contributor.authorFerreira, Ana Lucia A. [UNESP]
dc.contributor.authorMinatel, Igor Otavio [UNESP]
dc.contributor.authorCorrea, Camila Renata [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-04T12:14:53Z
dc.date.available2019-10-04T12:14:53Z
dc.date.issued2019-07-01
dc.description.abstractThe transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.en
dc.description.affiliationSao Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Inst Biosci, BR-18618689 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, BR-18618689 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2019/10972-6
dc.description.sponsorshipIdFAPESP: 2018/15294-3
dc.format.extent14
dc.identifierhttp://dx.doi.org/10.3390/ijms20133208
dc.identifier.citationInternational Journal Of Molecular Sciences. Basel: Mdpi, v. 20, n. 13, 14 p., 2019.
dc.identifier.doi10.3390/ijms20133208
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11449/184586
dc.identifier.wosWOS:000477041100096
dc.language.isoeng
dc.publisherMdpi
dc.relation.ispartofInternational Journal Of Molecular Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectNrf2
dc.subjectage-related disorders
dc.subjectoxidative stress
dc.titleBasic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseasesen
dc.typeResenha
dcterms.rightsHolderMdpi
unesp.author.lattes2940051650846541[8]
unesp.author.orcid0000-0002-3670-243X[3]
unesp.author.orcid0000-0002-9922-2871[9]
unesp.author.orcid0000-0002-5267-1127[8]

Arquivos

Coleções

Artigos