Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus

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dc.contributor.authorCampanella, Nathália C
dc.contributor.authorLacerda, Croider Franco
dc.contributor.authorBerardinelli, Gustavo Noriz
dc.contributor.authorAbrahão-Machado, Lucas Faria
dc.contributor.authorCruvinel-Carloni, Adriana
dc.contributor.authorDe Oliveira, Antônio Talvane Torres
dc.contributor.authorScapulatempo-Neto, Cristovam
dc.contributor.authorCrema, Eduardo
dc.contributor.authorAdad, Sheila Jorge
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.authorHenry, Maria Aparecida Coelho Arruda [UNESP]
dc.contributor.authorGuimarães, Denise Peixoto
dc.contributor.authorReis, Rui Manuel
dc.contributor.institutionBarretos Cancer Hospital
dc.contributor.institutionUFTM -Federal University of Triângulo Mineiro
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Minho
dc.contributor.institutionPT Government Assoc. Laboratory
dc.date.accessioned2018-12-11T17:21:11Z
dc.date.available2018-12-11T17:21:11Z
dc.date.issued2018-06-01
dc.description.abstractAim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene. Discussion/conclusion: Taking together, we concluded that MSI is a rare event in esophageal squamous cell carcinoma, but can be associated with CM.en
dc.description.affiliationMolecular Oncology Research Center Barretos Cancer Hospital
dc.description.affiliationDepartment of Digestive Surgery Barretos Cancer Hospital
dc.description.affiliationDepartment of Pathology and Molecular Diagnostics Barretos Cancer Hospital
dc.description.affiliationDepartment of Digestive Surgery and Pathology Medical School UFTM -Federal University of Triângulo Mineiro
dc.description.affiliationDepartment of Gastroenterology Surgery and Pathology Medical School UNESP - São Paulo State University
dc.description.affiliationDepartment of Endoscopy Barretos Cancer Hospital
dc.description.affiliationLife and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho
dc.description.affiliationICVS/3B's PT Government Assoc. Laboratory
dc.description.affiliationUnespDepartment of Gastroenterology Surgery and Pathology Medical School UNESP - São Paulo State University
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 476192/2013-7
dc.format.extent573-582
dc.identifierhttp://dx.doi.org/10.2217/bmm-2017-0329
dc.identifier.citationBiomarkers in Medicine, v. 12, n. 6, p. 573-582, 2018.
dc.identifier.doi10.2217/bmm-2017-0329
dc.identifier.issn1752-0371
dc.identifier.issn1752-0363
dc.identifier.scopus2-s2.0-85049204866
dc.identifier.urihttp://hdl.handle.net/11449/176520
dc.language.isoeng
dc.relation.ispartofBiomarkers in Medicine
dc.relation.ispartofsjr0,750
dc.relation.ispartofsjr0,750
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChagas disease
dc.subjectchagasic megaesophagus
dc.subjectesophageal squamous cell carcinoma
dc.subjectHSP10
dc.subjectmicrosatellite instability
dc.subjectmismatch repair
dc.subjectMSH6
dc.titlePresence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagusen
dc.typeResenha

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