Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus
dc.contributor.author | Campanella, Nathália C | |
dc.contributor.author | Lacerda, Croider Franco | |
dc.contributor.author | Berardinelli, Gustavo Noriz | |
dc.contributor.author | Abrahão-Machado, Lucas Faria | |
dc.contributor.author | Cruvinel-Carloni, Adriana | |
dc.contributor.author | De Oliveira, Antônio Talvane Torres | |
dc.contributor.author | Scapulatempo-Neto, Cristovam | |
dc.contributor.author | Crema, Eduardo | |
dc.contributor.author | Adad, Sheila Jorge | |
dc.contributor.author | Rodrigues, Maria Aparecida Marchesan [UNESP] | |
dc.contributor.author | Henry, Maria Aparecida Coelho Arruda [UNESP] | |
dc.contributor.author | Guimarães, Denise Peixoto | |
dc.contributor.author | Reis, Rui Manuel | |
dc.contributor.institution | Barretos Cancer Hospital | |
dc.contributor.institution | UFTM -Federal University of Triângulo Mineiro | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | University of Minho | |
dc.contributor.institution | PT Government Assoc. Laboratory | |
dc.date.accessioned | 2018-12-11T17:21:11Z | |
dc.date.available | 2018-12-11T17:21:11Z | |
dc.date.issued | 2018-06-01 | |
dc.description.abstract | Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene. Discussion/conclusion: Taking together, we concluded that MSI is a rare event in esophageal squamous cell carcinoma, but can be associated with CM. | en |
dc.description.affiliation | Molecular Oncology Research Center Barretos Cancer Hospital | |
dc.description.affiliation | Department of Digestive Surgery Barretos Cancer Hospital | |
dc.description.affiliation | Department of Pathology and Molecular Diagnostics Barretos Cancer Hospital | |
dc.description.affiliation | Department of Digestive Surgery and Pathology Medical School UFTM -Federal University of Triângulo Mineiro | |
dc.description.affiliation | Department of Gastroenterology Surgery and Pathology Medical School UNESP - São Paulo State University | |
dc.description.affiliation | Department of Endoscopy Barretos Cancer Hospital | |
dc.description.affiliation | Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho | |
dc.description.affiliation | ICVS/3B's PT Government Assoc. Laboratory | |
dc.description.affiliationUnesp | Department of Gastroenterology Surgery and Pathology Medical School UNESP - São Paulo State University | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorshipId | CNPq: 476192/2013-7 | |
dc.format.extent | 573-582 | |
dc.identifier | http://dx.doi.org/10.2217/bmm-2017-0329 | |
dc.identifier.citation | Biomarkers in Medicine, v. 12, n. 6, p. 573-582, 2018. | |
dc.identifier.doi | 10.2217/bmm-2017-0329 | |
dc.identifier.issn | 1752-0371 | |
dc.identifier.issn | 1752-0363 | |
dc.identifier.scopus | 2-s2.0-85049204866 | |
dc.identifier.uri | http://hdl.handle.net/11449/176520 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biomarkers in Medicine | |
dc.relation.ispartofsjr | 0,750 | |
dc.relation.ispartofsjr | 0,750 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | Chagas disease | |
dc.subject | chagasic megaesophagus | |
dc.subject | esophageal squamous cell carcinoma | |
dc.subject | HSP10 | |
dc.subject | microsatellite instability | |
dc.subject | mismatch repair | |
dc.subject | MSH6 | |
dc.title | Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus | en |
dc.type | Resenha |