Toxicogenetic monitoring in urban cities exposed to different airborne contaminants

dc.contributor.authorPereira, Tatiana S.
dc.contributor.authorBeltrami, Laiana S.
dc.contributor.authorRocha, Jocelita A.V.
dc.contributor.authorBroto, Francesc P.
dc.contributor.authorComellas, Lluis R.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorVargas, Vera M.F.
dc.contributor.institutionFundação Estadual de Proteção Ambiental Henrique uis Roessler (FEPAM)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversitat Ramon Llull (URL)-Barcelona
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:45Z
dc.date.available2014-05-27T11:28:45Z
dc.date.issued2013-04-01
dc.description.abstractMicroparticles found in the air may be associated with organic matter that contains several compounds, such as Polycyclic Aromatic Hydrocarbons (PAHs) and nitro-PAHs, and may pose a significant risk to human health, possibly leading to DNA mutations and cancers. This study associated genotoxicity assays for evaluating human exposure with the atmospheric air of two urban areas in southern Brazil, that received different atmospheric contributions. Site 1 was under urban-industrial influence and the other was a non-industrial reference, Site 2. Organic extracts from the airborne particulate matter were tested for mutagenicity via the Salmonella/microsome assay and analyzed for PAH composition. Cells samples of people residing in these two cities were evaluated using the comet and micronucleus assay (MN).Concentrations of the individual PAHs ranged from 0.01ng/m3 (benzo[a]anthracene) to 5.08ng/m3 (benzo[ghi]perylene). As to mutagenicity analysis of airborne, Site 1 presented all the mutagenic responses, which varied from 3.2±1.22rev/m3 (TA98 no S9) to 32.6±2.05rev/m3 (TA98, S9), while Site 2 ranged from negative to minimal responses. Site 1 presented a high quantity of nitro and amino derivatives of PAHs, and peaked at 56.0±3.68rev/μg (YG1024 strain). The two groups presented very low DNA damage levels without intergroup difference. Although Site 1 presented high mutagenic responses in the air samples, high PAH levels, healthy people exposed to this environment did not show significative damage in their genetic material. However, the evaluation of different environmental and genetic damage in such population is necessary to monitor possible damages. © 2013 Elsevier Inc.en
dc.description.affiliationFundação Estadual de Proteção Ambiental Henrique uis Roessler (FEPAM), Avenida Dr. Salvador França 1707, Porto Alegre RS, Postal Code 90690-000
dc.description.affiliationPrograma de Pós-graduação em Ecologia Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS
dc.description.affiliationLaboratorio de Cromatografia Institut Químic de Sarrià (IQS) Universitat Ramon Llull (URL)-Barcelona, Postal Code: 08017
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista-(UNESP), Botucatu, SP, Postal Code 18618-970
dc.description.affiliationUnespDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista-(UNESP), Botucatu, SP, Postal Code 18618-970
dc.format.extent174-182
dc.identifierhttp://dx.doi.org/10.1016/j.ecoenv.2012.12.029
dc.identifier.citationEcotoxicology and Environmental Safety, v. 90, p. 174-182.
dc.identifier.doi10.1016/j.ecoenv.2012.12.029
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.lattes5051118752980903
dc.identifier.scopus2-s2.0-84874280888
dc.identifier.urihttp://hdl.handle.net/11449/74920
dc.identifier.wosWOS:000315840000025
dc.language.isoeng
dc.relation.ispartofEcotoxicology and Environmental Safety
dc.relation.ispartofjcr3.974
dc.relation.ispartofsjr1,201
dc.relation.ispartofsjr1,201
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectComet assay
dc.subjectHuman environmental exposure
dc.subjectMutagenicity
dc.subjectPolycyclic aromatic hydrocarbon
dc.subjectSalmonella/microsome assay
dc.subjectTotal airborne particulate matter
dc.subjectDNA
dc.subjectorganic matter
dc.subjectpolycyclic aromatic hydrocarbon
dc.subjectassay
dc.subjectatmospheric pollution
dc.subjectenvironmental risk
dc.subjectgenotoxicity
dc.subjecthealth risk
dc.subjectmutagenicity
dc.subjectPAH
dc.subjectparticulate matter
dc.subjectpollution exposure
dc.subjectpublic health
dc.subjecturban pollution
dc.subjectairborne particle
dc.subjectbiological monitoring
dc.subjectBrazil
dc.subjectcity
dc.subjectDNA damage
dc.subjectenvironmental factor
dc.subjectenvironmental monitoring
dc.subjecthealth hazard
dc.subjectheredity
dc.subjectmicrosome
dc.subjectSalmonella
dc.subjecttoxicogenetics
dc.subjecturban area
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAir Pollutants
dc.subjectCities
dc.subjectDNA Damage
dc.subjectHumans
dc.subjectMutagenicity Tests
dc.subjectParticulate Matter
dc.subjectPolycyclic Hydrocarbons, Aromatic
dc.subjectYoung Adult
dc.titleToxicogenetic monitoring in urban cities exposed to different airborne contaminantsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[6]
unesp.author.orcid0000-0002-9330-4841[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt

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