Publicação: Breast cancer subtype specific biochemical responses to radiation
dc.contributor.author | Meksiarun, Phiranuphon | |
dc.contributor.author | Aoki, Pedro H. B. [UNESP] | |
dc.contributor.author | Van Nest, Samantha J. | |
dc.contributor.author | Sobral-Filho, Regivaldo Gomes | |
dc.contributor.author | Lum, Julian J. | |
dc.contributor.author | Brolo, Alexandre G. | |
dc.contributor.author | Jirasek, Andrew | |
dc.contributor.institution | University of British Columbia-Okanagan | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | University of Victoria | |
dc.contributor.institution | BC Cancer Agency Vancouver Island Cancer Centre | |
dc.date.accessioned | 2018-12-11T16:54:53Z | |
dc.date.available | 2018-12-11T16:54:53Z | |
dc.date.issued | 2018-08-21 | |
dc.description.abstract | External beam radiotherapy is a common form of treatment for breast cancer. Among patients and across different breast cancer subtypes, the response to radiation is heterogeneous. Radiation-induced biochemical changes were examined by Raman spectroscopy using cell lines that represent a spectrum of human breast cancer. Principal component analysis (PCA) and partial least squares discriminant analysis (PLSDA) revealed unique Raman spectral features in the HER2 and Ki67 subtype. The changes in Raman spectral profiles to different doses of radiation (0-50 Gy) included variations in the levels of proteins, lipids, nucleic acids and glycogen. Importantly, the differences in radiation-induced changes on the normal breast epithelial cell line MCF10A could be discriminated within and across the various breast tumor cell lines. These results demonstrate a novel approach to uncover differences between breast cancer cell subtypes and surrounding normal tissues by their biochemical variations in response to radiation. | en |
dc.description.affiliation | Department of Physics I.K. Barber School of Arts and Sciences University of British Columbia-Okanagan | |
dc.description.affiliation | São Paulo State University (UNESP) School of Sciences Humanities and Languages | |
dc.description.affiliation | University of Victoria Department of Physics and Astronomy, PO Box 1700 STN CSC | |
dc.description.affiliation | University of Victoria Department of Chemistry, PO Box 1700 | |
dc.description.affiliation | University of Victoria Department of Biochemistry and Microbiology, PO Box 1700 STN CSC | |
dc.description.affiliation | Trev and Joyce Deeley Research Centre BC Cancer Agency Vancouver Island Cancer Centre, 2410 Lee Ave | |
dc.description.affiliationUnesp | São Paulo State University (UNESP) School of Sciences Humanities and Languages | |
dc.format.extent | 3850-3858 | |
dc.identifier | http://dx.doi.org/10.1039/c8an00345a | |
dc.identifier.citation | Analyst, v. 143, n. 16, p. 3850-3858, 2018. | |
dc.identifier.doi | 10.1039/c8an00345a | |
dc.identifier.issn | 1364-5528 | |
dc.identifier.issn | 0003-2654 | |
dc.identifier.lattes | 7384168674539702 | |
dc.identifier.orcid | 0000-0003-4701-6408 | |
dc.identifier.scopus | 2-s2.0-85051408003 | |
dc.identifier.uri | http://hdl.handle.net/11449/171326 | |
dc.language.iso | eng | |
dc.relation.ispartof | Analyst | |
dc.relation.ispartofsjr | 1,249 | |
dc.relation.ispartofsjr | 1,249 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.title | Breast cancer subtype specific biochemical responses to radiation | en |
dc.type | Artigo | |
dspace.entity.type | Publication | |
unesp.author.lattes | 7384168674539702[2] | |
unesp.author.orcid | 0000-0003-4701-6408[2] |