Effects of low doses of polyunsaturated fatty acids on the attention deficit/Hyperactivity disorder of children: A systematic review

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Grassmann, Viviane
Santos-Galduróz, Ruth Ferreira [UNESP]
Galduróz, José Carlos Fernandes

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Since attention deficit/hyperactivity disorder (ADHD) presents high prevalence among children, science has been researching alternative forms of treatment that do not involve medication. Objective: To evaluate the effects of polyunsaturated fatty acids (PUFAs) on attention deficit/hyperactivity disorder. Methods: We reviewed the articles published between 1980 and 2012 indexed in the databases PubMed, APA psychNET, Scopus and Web of Knowledge. Results: Initially 231 articles were selected, out of which 12 met the inclusion criteria. The articles selected reported a modest cognitive and behavioral improvement of the patients after treatment with low doses of PUFAs. Those results might be associated with the evaluation methodology, the doses of PUFAs administered or the duration of treatment. © 2013 Bentham Science Publishers.



Attention deficit/Hyperactivity disorder, Behavior, Children, Cognition, Dietary supplements and polyunsaturated fatty acids, amphetamine, arachidonic acid, dexamphetamine, docosahexaenoic acid, efalex, fish oil, gamma linolenic acid, icosapentaenoic acid, linolenic acid, linseed oil, methylphenidate, multivitamin, omega 3 fatty acid, omega 6 fatty acid, placebo, polyunsaturated fatty acid, primrose oil, sunflower oil, unclassified drug, anxiety, attention deficit disorder, behavior, cognition, comorbidity, drug megadose, DSM-IV, human, hyperactivity, impulsiveness, nonhuman, randomized controlled trial (topic), review, systematic review

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Current Neuropharmacology, v. 11, n. 2, p. 186-196, 2013.