Poly-ε-caprolactone nanoparticles loaded with 4-nerolidylcatechol (4-nc) for growth inhibition of microsporum canis

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Greatti, Vanessa Raquel [UNESP]
Oda, Fernando [UNESP]
Sorrechia, Rodrigo [UNESP]
Kapp, Bárbara Regina [UNESP]
Seraphim, Carolina Manzato [UNESP]
Weckwerth, Ana Carolina Villas Bôas
Chorilli, Marlus [UNESP]
Da Silva, Patrícia Bento [UNESP]
Eloy, Josimar O.
Kogan, Marcelo J.
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Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound’s stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC.
4-Nerolidylcatechol, Antifungals, Microsporum canis, Nanoparticles, Nanoprecipitation, Polycaprolactone
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Antibiotics, v. 9, n. 12, p. 1-16, 2020.