Thermal behavior of some antihistamines
dc.contributor.author | Perpétuo, G. L. [UNESP] | |
dc.contributor.author | Gálico, D. A. [UNESP] | |
dc.contributor.author | Fugita, R. A. [UNESP] | |
dc.contributor.author | Castro, R. A E | |
dc.contributor.author | Eusébio, M. E S | |
dc.contributor.author | Treu-Filho, O. [UNESP] | |
dc.contributor.author | Silva, A. C M [UNESP] | |
dc.contributor.author | Bannach, Gilbert [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de Coimbra | |
dc.date.accessioned | 2014-05-27T11:28:33Z | |
dc.date.available | 2014-05-27T11:28:33Z | |
dc.date.issued | 2013-03-01 | |
dc.description.abstract | Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG-DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG-DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases. © 2012 Akadémiai Kiadó, Budapest, Hungary. | en |
dc.description.affiliation | Departamento de Química Falculdade de Ciências UNESP, Bauru, SP, CEP 17033-260 | |
dc.description.affiliation | CEF Faculdade de Farmácia Universidade de Coimbra, CEP 3000-548, Coimbra | |
dc.description.affiliation | CQC Departamento de Química Universidade de Coimbra, CEP 3004-535, Coimbra | |
dc.description.affiliation | Instituto de Química - UNESP, Araraquara, SP, CEP 14800-900 | |
dc.description.affiliationUnesp | Departamento de Química Falculdade de Ciências UNESP, Bauru, SP, CEP 17033-260 | |
dc.description.affiliationUnesp | Instituto de Química - UNESP, Araraquara, SP, CEP 14800-900 | |
dc.format.extent | 2019-2028 | |
dc.identifier | http://dx.doi.org/10.1007/s10973-012-2247-0 | |
dc.identifier.citation | Journal of Thermal Analysis and Calorimetry, v. 111, n. 3, p. 2019-2028, 2013. | |
dc.identifier.doi | 10.1007/s10973-012-2247-0 | |
dc.identifier.issn | 1388-6150 | |
dc.identifier.scopus | 2-s2.0-84881475988 | |
dc.identifier.uri | http://hdl.handle.net/11449/74643 | |
dc.identifier.wos | WOS:000315298800048 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Thermal Analysis and Calorimetry | |
dc.relation.ispartofjcr | 2.209 | |
dc.relation.ispartofsjr | 0,587 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | Antihistamines | |
dc.subject | Cimetidine | |
dc.subject | Famotidine | |
dc.subject | Nizatidine | |
dc.subject | Ranitidine | |
dc.subject | Thermal behavior | |
dc.subject | Thermal behaviors | |
dc.subject | Differential scanning calorimetry | |
dc.subject | Infrared spectroscopy | |
dc.subject | Thermogravimetric analysis | |
dc.subject | X ray powder diffraction | |
dc.subject | Melting | |
dc.title | Thermal behavior of some antihistamines | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights | |
unesp.author.orcid | 0000-0002-8790-5069[8] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências, Bauru | pt |
unesp.department | Química - FC | pt |