Cyclooxigenase-2 expression in primary metastatic and non metastatic canine mammarian carcinomas

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De Nardi, A. B. [UNESP]
Daleck, C. R. [UNESP]
Amorin, R. L. [UNESP]
Huppes, R. R. [UNESP]
Uscategui, R. A. R. [UNESP]
Rodaski, S.
Calderon, C.
Neto, R. T. [UNESP]

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Univ Austral Chile, Fac Ciencias Veterinarias


The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry analysis, using the primary polyclonal antibody anti-PGHS-2, clone PG 27, (Oxford Biomedical Research). The number of marked cells by the COX-2 antibody was higher (P < 0.001) in the metastatic primary carcinoma (81.25%) than non-metastatic (60.3%). There was a positive correlation between the number of labeled cells.



Cancer, Mammary neoplasm, ciclooxigenase-2, Dog

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Archivos De Medicina Veterinaria. Valdivia: Univ Austral Chile, Fac Ciencias Veterinarias, v. 45, n. 3, p. 311-316, 2013.