Calcium Supplementation on Glucose Tolerance, Oxidative Stress, and Reproductive Outcomes of Diabetic Rats and Their Offspring

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dc.contributor.authorKlöppel, Eduardo [UNESP]
dc.contributor.authorSouza, Maysa Rocha [UNESP]
dc.contributor.authorBarco, Vinícius Soares [UNESP]
dc.contributor.authorGallego, Franciane Quintanilha [UNESP]
dc.contributor.authorSinzato, Yuri Karen [UNESP]
dc.contributor.authorCorrente, José Eduardo [UNESP]
dc.contributor.authorRodrigues, Tiago
dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionMato Grosso State
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2023-07-29T13:48:56Z
dc.date.available2023-07-29T13:48:56Z
dc.date.issued2023-01-01
dc.description.abstractDiabetes mellitus increases the risk of obstetric complications, morbidity, and infant mortality. Controlled nutritional therapy with micronutrients has been employed. However, the effect of calcium (Ca2+) supplementation on diabetic pregnancy is unclear. We aimed to evaluate whether diabetic rats supplemented with Ca2+ during pregnancy present better glucose tolerance, redox status, embryonic and fetal development, newborn weight, and the prooxidant and antioxidant balance of male and female pups. For this, newborn rats received the beta-cytotoxic drug streptozotocin for inducing diabetes on the day of birth. In adulthood, these rats were mated and treated with Ca2+ twice a day from day 0 to day 20 of pregnancy. On day 17, the pregnant rats were submitted to the oral glucose tolerance test (OGTT). At the end of pregnancy, they were anesthetized and killed to collect blood and pancreas samples. The uterine horns were exposed for an evaluation of maternal reproductive outcomes and embryofetal development, and the offspring’s liver samples were collected for redox status measurement. Nondiabetic and diabetic rats supplemented with Ca2+ showed no influence on glucose tolerance, redox status, insulin synthesis, serum calcium levels, and embryofetal losses. The reduced rate of newborns classified as adequate for gestational age (AGA) and higher rates of LGA (large) and small (LGA) newborns and higher -SH and GSH-Px antioxidant activities in female pups were observed in diabetic dams, regardless of supplementation. Thus, maternal supplementation caused no improvement in glucose tolerance, oxidative stress biomarkers, embryofetal growth and development, and antioxidants in pups from diabetic mothers.en
dc.description.affiliationLaboratory of Experimental Research On Gynecology and Obstetrics Postgraduate Course On Tocogynecology Botucatu Medical School São Paulo State University_UNESP, São Paulo State
dc.description.affiliationLaboratory of System Physiology and Reproductive Toxicology Federal University of Mato Grosso_UFMT Mato Grosso State
dc.description.affiliationResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State
dc.description.affiliationCenter for Natural and Human Sciences (CCNH) Federal University of ABC (UFABC), Santo André, SP
dc.description.affiliationUnespLaboratory of Experimental Research On Gynecology and Obstetrics Postgraduate Course On Tocogynecology Botucatu Medical School São Paulo State University_UNESP, São Paulo State
dc.description.affiliationUnespResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State
dc.identifierhttp://dx.doi.org/10.1007/s43032-023-01217-9
dc.identifier.citationReproductive Sciences.
dc.identifier.doi10.1007/s43032-023-01217-9
dc.identifier.issn1933-7205
dc.identifier.issn1933-7191
dc.identifier.scopus2-s2.0-85151467693
dc.identifier.urihttp://hdl.handle.net/11449/248616
dc.language.isoeng
dc.relation.ispartofReproductive Sciences
dc.sourceScopus
dc.subjectCalcium
dc.subjectHyperglycemia
dc.subjectPregnancy
dc.subjectRedox status
dc.subjectRodent
dc.titleCalcium Supplementation on Glucose Tolerance, Oxidative Stress, and Reproductive Outcomes of Diabetic Rats and Their Offspringen
dc.typeArtigo
unesp.author.orcid0000-0001-8402-2407[1]
unesp.author.orcid0000-0002-2144-5004[2]
unesp.author.orcid0000-0003-1759-0011[3]
unesp.author.orcid0000-0002-6081-7763[4]
unesp.author.orcid0000-0002-2973-1099[5]
unesp.author.orcid0000-0001-5478-4996[6]
unesp.author.orcid0000-0003-1277-0224[7]
unesp.author.orcid0000-0002-4753-3264[8]
unesp.author.orcid0000-0002-7003-9643[9]

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Artigos - Ginecologia e Obstetrícia - FMB