New small molecules in dermatology: for the autoimmunity, inflammation and beyond

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dc.contributor.authorCriado, Paulo Ricardo
dc.contributor.authorLorenzini, Daniel
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.authorBueno-Filho, Roberto
dc.contributor.authorCarneiro, Francisca Regina Oliveira
dc.contributor.authorIanhez, Mayra
dc.contributor.institutionSanto André
dc.contributor.institutionSanta Casa de Misericórida de Porto Alegre
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUEPA—Belém
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2023-07-29T16:14:22Z
dc.date.available2023-07-29T16:14:22Z
dc.date.issued2023-01-01
dc.description.abstractObjective and design: The discovery of new inflammatory pathways and the mechanism of action of inflammatory, autoimmune, genetic, and neoplastic diseases led to the development of immunologically driven drugs. We aimed to perform a narrative review regarding the rising of a new class of drugs capable of blocking important and specific intracellular signals in the maintenance of these pathologies: the small molecules. Materials/methods: A total of 114 scientific papers were enrolled in this narrative review. Results: We describe in detail the families of protein kinases—Janus Kinase (JAK), Src kinase, Syk tyrosine kinase, Mitogen-Activated Protein Kinase (MAPK), and Bruton Tyrosine Kinase (BTK)—their physiologic function and new drugs that block these pathways of intracellular signaling. We also detail the involved cytokines and the main metabolic and clinical implications of these new medications in the field of dermatology. Conclusions: Despite having lower specificity compared to specific immunobiological therapies, these new drugs are effective in a wide variety of dermatological diseases, especially diseases that had few therapeutic options, such as psoriasis, psoriatic arthritis, atopic dermatitis, alopecia areata, and vitiligo.en
dc.description.affiliationFaculdade de Medicina Do ABC Post-Graduation Program Full Researcher Santo André, Rua Carneiro Leão 33, Vila Scarpelli, Santo André
dc.description.affiliationSanta Casa de Misericórida de Porto Alegre, RS
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), São Paulo
dc.description.affiliationRibeirão Preto Medical School—University of São Paulo
dc.description.affiliationUniversidade Do Estado Do Pará UEPA—Belém
dc.description.affiliationUniversidade Federal de Goiás (UFG) E Hospital de Doenças Tropicais (HDT-GO), Goiás
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), São Paulo
dc.identifierhttp://dx.doi.org/10.1007/s00011-023-01744-w
dc.identifier.citationInflammation Research.
dc.identifier.doi10.1007/s00011-023-01744-w
dc.identifier.issn1420-908X
dc.identifier.issn1023-3830
dc.identifier.scopus2-s2.0-85160104113
dc.identifier.urihttp://hdl.handle.net/11449/249977
dc.language.isoeng
dc.relation.ispartofInflammation Research
dc.sourceScopus
dc.subjectAtopic
dc.subjectDermatitis
dc.subjectJanus kinases
dc.subjectMitogen-activated protein kinase kinases
dc.subjectSrc-family kinases
dc.subjectSyk Kinase
dc.titleNew small molecules in dermatology: for the autoimmunity, inflammation and beyonden
dc.typeResenha
unesp.author.orcid0000-0001-9785-6099[1]
unesp.author.orcid0000-0002-6850-5799[2]
unesp.author.orcid0000-0002-2596-9294[3]
unesp.author.orcid0000-0003-2871-0306[4]
unesp.author.orcid0000-0001-6735-4004[5]
unesp.author.orcid0000-0003-3604-3128[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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Botucatu - FMB - Faculdade de Medicina