Cardiovascular Disease Parameters in Periodontitis

dc.contributor.authorMonteiro, Andrea M.
dc.contributor.authorJardini, Maria Aparecida Neves [UNESP]
dc.contributor.authorAlves, Sarah
dc.contributor.authorGiarnpaoli, Viviana
dc.contributor.authorAubin, Elisete C. Q.
dc.contributor.authorFigueiredo Neto, Antonio M.
dc.contributor.authorGidlund, Magnus
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:49Z
dc.date.available2014-05-20T14:04:49Z
dc.date.issued2009-03-01
dc.description.abstractBackground: Recently, there has been an increasing in the impact of oral health on atherosclerosis and subsequent cardiovascular disease. The aim of this study is to investigate the association between chronic periodontitis and cardiovascular risk markers.Methods: Forty patients with periodontitis and 40 healthy gender-, body mass index-, and age-matched individuals were compared by measuring total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, levels of cytokines, antibodies against oxidized low-density lipoprotein, thiobarbituric acid reactive substances, total and differential white blood cell counts, and the non-linear index of refraction.Results: The levels of triglycerides and high-density lipoprotein in periodontitis patients were significantly higher and lower, respectively (P=0.002 and P=0.0126), compared to controls. Total cholesterol, low-density lipoprotein, and lipid peroxide levels were the same in both groups (P = 0.2943, P = 0.1284, and P = 0.067, respectively). Interleukin (IL)-6 and -8, antibodies against oxidized low-density lipoprotein, and leukocyte and neutrophil counts were significantly higher in periodontitis patients (P<0.05). The value of the non-linear index of refraction of low-density lipoprotein solutions was higher in the controls (P = 0.015) compared to individuals with periodontitis.Conclusion: Our results confirmed and further strengthened the suggested association between coronary artery disease and periodontitis. J Periodontol 2009;80:378-388.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, BR-05508900 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv São Paulo, Inst Phys, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Math & Stat, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, Brazil
dc.format.extent378-388
dc.identifierhttp://dx.doi.org/10.1902/jop.2009.080431
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 80, n. 3, p. 378-388, 2009.
dc.identifier.doi10.1902/jop.2009.080431
dc.identifier.issn0022-3492
dc.identifier.lattes5733639342016958
dc.identifier.urihttp://hdl.handle.net/11449/22729
dc.identifier.wosWOS:000264256700004
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntibodiesen
dc.subjectatherosclerosisen
dc.subjectcardiovascularen
dc.subjectoxLDLen
dc.subjectperiodontitisen
dc.subjectrisk factorsen
dc.titleCardiovascular Disease Parameters in Periodontitisen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/page/permissionRequests.jsp
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.lattes5733639342016958
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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