Hepatitis C infection: challenges in dental management and diagnosis of extrahepatic manifestations

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dc.contributor.authorKanno, Cláudia Misue [UNESP]
dc.contributor.authorCastro, Alvimar Lima de [UNESP]
dc.contributor.authorCrivelini, Marcelo Macedo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:55:39Z
dc.date.available2016-01-28T16:55:39Z
dc.date.issued2012
dc.description.abstractHepatitis C is associated with autoimmune diseases, hepatocellular carcinoma,and extrahepatic manifestations that, in conjunction, may seriously compromise the patient's quality of life. We herein describe a case of chronic hepatitis C with oral manifestations and discuss some implications for diagnosis and treatment. A 63-year-old woman complaining of spontaneous bleeding of the oral mucosa presented with bilateral asymmetric ulcers surrounded by white papules and striae on the buccal mucosa. Her medical history revealed leucopenia, thrombocytopenia, and skin lesions associated with chronic hepatitis C. Propranolol and ranitidine had recently been prescribed. Lichen planus, lichenoid reaction, and erythema multiforme were considered in the differential diagnosis. Histopathological analysis revealed lymphocytic infiltrate in a lichenoid pattern. The lesions partially healed after 1 week and completely regressed after 6 months, despite the maintenance of all medications; no recurrence was observed. The final diagnosis was oral lichen planus associated with hepatitis C. Chronic hepatitis C may present oral manifestations, which demand adjustments in dental treatment planning. Medication side effects may interfere with the clinical presentation and course of the disease and should be accounted for in the differential diagnosis. The possibility of spontaneous remission of oral lichen planus should always be considered, especially when putative etiological factors of a lichenoid lesion are withdrawn in an attempt to differentiate oral lichen planus from lichenoid lesions. This case emphasizes the importance of recognizing the extrahepatic manifestations of hepatitis C as a cause of increased morbidity.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Odontologia de Araçatuba, Aracatuba, Rua José Bonifácio, 1193, Vila Mendonça, CEP 16015-050, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Odontologia de Araçatuba, Department of Pathology and Clinical Propaedeutics - Araçatuba, Rua José Bonifácio, 1193, Vila Mendonça, CEP 16015-050, SP, Brasil
dc.format.extent15-19
dc.identifierhttp://hepatitiscnewdrugresearch.com/hcv-dental-management-diagnosis-of-extrahepatic-manifestations.html
dc.identifier.citationJournal of Oral Diagnosis, v. 1, n. 1, p. 15-19, 2012.
dc.identifier.issn9999-999X
dc.identifier.lattes9544257482512671
dc.identifier.lattes8039557526741132
dc.identifier.urihttp://hdl.handle.net/11449/133568
dc.language.isoeng
dc.relation.ispartofJournal of Oral Diagnosis
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectChronic hepatitis cen
dc.subjectLeucopeniaen
dc.subjectOral diagnosisen
dc.subjectOral lichen planusen
dc.subjectThrombocytopeniaen
dc.titleHepatitis C infection: challenges in dental management and diagnosis of extrahepatic manifestationsen
dc.typeArtigo
unesp.author.lattes8039557526741132
unesp.author.lattes9544257482512671
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.departmentPatologiapt

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