Testes de biocompatibilidade in vitro de duas formas comerciais do agregado de trióxido mineral

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dc.contributor.authorRibeiro, Daniel Araki [UNESP]
dc.contributor.authorMatsumoto, Mariza Akemi
dc.contributor.authorDuarte, Marco Antonio Húngaro [UNESP]
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Sacred Heart
dc.date.accessioned2014-05-27T11:21:23Z
dc.date.available2014-05-27T11:21:23Z
dc.date.issued2005-07-01
dc.description.abstractRecently, regular and white mineral trioxide aggregate (MTA) are being used in Dentistry as retrofilling materials. Genotoxicity and cytotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. Thus, the goal of this study was to examine the genotoxicity and cytotoxicity of regular and white MTA in vitro by the single cell gel (comet) assay and trypan blue exclusion test, respectively. Mouse lymphoma cells were exposed to two presentation forms of MTA at final concentrations ranging from 1 to 1,000 μg/mL for 3 h at 37°C. The results showed that both compounds tested did not produce genotoxic effects at all concentrations evaluated. Likewise, no statistically significant differences (p > 0.05) were observed in cytotoxicity. Taken together, our results suggest that regular and white MTA are not genotoxins and are not able to interfere in cellular viability as assessed by single cell gel (comet) assay and trypan blue assay, respectively.en
dc.description.affiliationCenter for Genotoxin and Carcinogen Evaluation TOXICAN - Department of Pathology School of Medicine of Botucatu, São Paulo State University
dc.description.affiliationDepartment of Dental Clinics University of Sacred Heart
dc.description.affiliationUnespCenter for Genotoxin and Carcinogen Evaluation TOXICAN - Department of Pathology School of Medicine of Botucatu, São Paulo State University
dc.format.extent183-187
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242005000300005
dc.identifier.citationBrazilian Oral Research, v. 19, n. 3, p. 183-187, 2005.
dc.identifier.doi10.1590/S1806-83242005000300005
dc.identifier.file2-s2.0-33747570321.pdf
dc.identifier.issn1806-8324
dc.identifier.issn1807-3107
dc.identifier.lattes5051118752980903
dc.identifier.lattes7528116925519142
dc.identifier.lattes8621510886887389
dc.identifier.orcid0000-0001-5389-0105
dc.identifier.scieloS1806-83242005000300005
dc.identifier.scopus2-s2.0-33747570321
dc.identifier.urihttp://hdl.handle.net/11449/68320
dc.language.isopor
dc.relation.ispartofBrazilian Oral Research
dc.relation.ispartofjcr1.223
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectComet assay
dc.subjectGenotoxicity tests
dc.subjectMineral trioxide aggregate
dc.subjectMouse lymphoma cells
dc.subjectTrypan blue
dc.titleTestes de biocompatibilidade in vitro de duas formas comerciais do agregado de trióxido mineralpt
dc.title.alternativeIn vitro biocompatibility tests of two commercial types of mineral trioxide aggregateen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bor/iaboutj.htm
unesp.author.lattes5051118752980903
unesp.author.lattes7528116925519142
unesp.author.lattes8621510886887389
unesp.author.orcid0000-0001-6947-5627[4]
unesp.author.orcid0000-0001-5389-0105[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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