Publicação:
Cell-mediated immune response to Leishmania chagasi experimental infection of BALB/c immunosuppressed mice

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dc.contributor.authorMachado, J. G. [UNESP]
dc.contributor.authorHoffmann, J. L. [UNESP]
dc.contributor.authorKrause, V. L.K. [UNESP]
dc.contributor.authorda Silva, A. V. [UNESP]
dc.contributor.authorDias-Melicio, L. A. [UNESP]
dc.contributor.authorLangoni, H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T21:00:55Z
dc.date.available2022-04-28T21:00:55Z
dc.date.issued2010-01-01
dc.description.abstractLeishmaniasis, a zoonosis of worldwide distribution, presents a significant impact on immunosupressed patients. This study aimed to evaluate Leishmania chagasi infection in BALB/c mice immunosuppressed with dexamethasone. Spleen cells stimulated or not with L. chagasi were cultured for cytokine quantification (IFN-γ, IL-2, IL-4 and IL-10) by sandwich ELISA. Parasite loads in the spleen and liver were determined by means of culture microtitration. Immunosuppressed groups showed statistically lower spleen weight and CD4-cell percentage in blood on the day of infection and produced Th1 and Th2 cytokines on other days of the study. The other infected groups, weather immunosupressed or not, also produced Th1 and Th2 cytokines. Parasite loads in the spleen and liver were not statistically different among the groups. It was concluded that L. chagasi infection was not affected by dexamethasone-induced immunosuppression, probably due the reversible effect of the treatment.en
dc.description.affiliationZoonosis Research Center NUPEZO Veterinary Medicine and Animal Husbandry School São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartment of Microbiology and Immunology Botucatu Biosciences Institute São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespZoonosis Research Center NUPEZO Veterinary Medicine and Animal Husbandry School São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Microbiology and Immunology Botucatu Biosciences Institute São Paulo State University UNESP, Botucatu, São Paulo State
dc.format.extent131-146
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992010000100013
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 131-146, 2010.
dc.identifier.doi10.1590/S1678-91992010000100013
dc.identifier.issn1678-9199
dc.identifier.scopus2-s2.0-77950854148
dc.identifier.urihttp://hdl.handle.net/11449/225828
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.sourceScopus
dc.subjectImmunopathology
dc.subjectImmunosuppression
dc.subjectInterleukins
dc.subjectMice
dc.subjectVisceral leishmaniasis
dc.titleCell-mediated immune response to Leishmania chagasi experimental infection of BALB/c immunosuppressed miceen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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