Calorimetry, Morphometry, Oxidative Stress, and Cardiac Metabolic Response to Growth Hormone Treatment in Obese and Aged Rats

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dc.contributor.authorSeiva, F. R. F. [UNESP]
dc.contributor.authorChuffa, L. G. A. [UNESP]
dc.contributor.authorEbaid, Geovana Xavier [UNESP]
dc.contributor.authorSilva, T. [UNESP]
dc.contributor.authorFernandes, A. A. H. [UNESP]
dc.contributor.authorNovelli, E. L. B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:30:33Z
dc.date.available2014-05-20T15:30:33Z
dc.date.issued2011-06-01
dc.description.abstractThis study investigated the effects of growth hormone therapy on energy expenditure, lipid profile, oxidative stress and cardiac energy metabolism in aging and obesity conditions. Life expectancy is increasing in world population and with it, the incidence of public health problems such as obesity and cardiac alterations. Because growth hormone (GH) concentration is referred to be decreased in aging conditions, a question must be addressed: what is the effect of GH on aging related adverse changes? To investigate the effects of GH on cardiac energy metabolism and its association with calorimetric parameters, lipid profile and oxidative stress in aged and obese rats, initially 32 male Wistar rats were divided into 2 groups (n = 16), C: given standard-chow and water; H: given hypercaloric-chow and receiving 30 % sucrose in its drinking water. After 45 days, both C and H groups were divided into 2 subgroups (n = 8), C + PL: standard-chow, water, and receiving saline subcutaneously; C + GH: standard-chow, water, and receiving 2 mg/kg/day rhGH subcutaneously; H + PL: hypercaloric-chow, 30 % sucrose, receiving saline subcutaneously; H + GH: hypercaloric-chow, 30 % sucrose, receiving rhGH subcutaneously. After 30 days, C + GH and H + PL rats had higher body mass index, Lee-index, body fat content, percent-adiposity, serum triacylglycerol, cardiac lipid-hydroperoxide, and triacylglycerol than C + PL. Energy-expenditure (RMR)/body weight, oxygen consumption and fat-oxidation were higher in H + GH than in H + PL. LDL-cholesterol was highest in H + GH rats, whereas cardiac pyruvate-dehydrogenase and phosphofrutokinase were higher in H + GH and H + PL rats than in C + PL. In conclusion, the present study brought new insights on aging and obesity, demonstrating for the first time that GH therapy was harmful in aged and obesity conditions, impairing calorimetric parameters and lipid profile. GH was disadvantageous in control old rats, having undesirable effects on triacylglycerol accumulation and cardiac oxidative stress.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Med, Post Grad Course,Dept Clin & Cardiol, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Anat, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Med, Post Grad Course,Dept Clin & Cardiol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Anat, BR-18618000 São Paulo, Brazil
dc.format.extent397-403
dc.identifierhttp://dx.doi.org/10.1055/s-0031-1273769
dc.identifier.citationHormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 43, n. 6, p. 397-403, 2011.
dc.identifier.doi10.1055/s-0031-1273769
dc.identifier.issn0018-5043
dc.identifier.lattes5121319676503034
dc.identifier.urihttp://hdl.handle.net/11449/39902
dc.identifier.wosWOS:000291095400006
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofHormone and Metabolic Research
dc.relation.ispartofjcr2.560
dc.relation.ispartofsjr0,918
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgrowth hormoneen
dc.subjectobesityen
dc.subjectagingen
dc.subjectcardiac energy metabolismen
dc.titleCalorimetry, Morphometry, Oxidative Stress, and Cardiac Metabolic Response to Growth Hormone Treatment in Obese and Aged Ratsen
dc.typeArtigo
dcterms.licensehttps://www.thieme.de/cps/rde/xbcr/classic/thieme_ir_policy_english.pdf
dcterms.rightsHolderGeorg Thieme Verlag Kg
unesp.author.lattes5121319676503034
unesp.author.lattes0077247086732148[5]
unesp.author.orcid0000-0002-7461-8773[1]
unesp.author.orcid0000-0002-0199-3396[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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