Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD

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dc.contributor.authorRamos, D. [UNESP]
dc.contributor.authorProença, M.
dc.contributor.authorLeite, M. R.
dc.contributor.authorFerreira, A. D. [UNESP]
dc.contributor.authorTrevisan, I. B. [UNESP]
dc.contributor.authorBrígida, G. F.S. [UNESP]
dc.contributor.authorTacao, G. Y. [UNESP]
dc.contributor.authorRamos, E. M.C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionJacarezinho
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPresidente Prudente
dc.date.accessioned2018-12-11T17:15:48Z
dc.date.available2018-12-11T17:15:48Z
dc.date.issued2017-09-01
dc.description.abstractIntroduction Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR. Methods 35 subjects were divided into three groups: individuals with COPD who received PR (G1, n = 15), those who did not (G2, n = 10), and a control group composed of healthy individuals without COPD (CG, n = 10). Measurements of lung function and concentrations of IL-6, IL-10, and TNF-α in exhaled breath condensate samples were collected. The assessment and concentrations of particulate matter (PM10), nitrogen dioxide (NO2), ozone (O3), temperature (T), and relative air humidity (RAH) were recorded in biomass burning and non-burning periods. Results There was a significant increase in the concentrations of air pollutants in the biomass burning period. In this period, an increase in IL-6 (G1p = 0.041, G2 p =.012), and a reduction in the FEV1/FVC ratio (G1p = 0.021, G2 p =.007) were observed in individuals with COPD. In G1, the increase in IL-6 concentrations correlated positively with O3 (r = 0.693; p =.006), and negatively with RAH (r = −0.773; p =.003) in the burning period. Conclusions Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV1/FVC ratio, regardless of their engagement in PR.en
dc.description.affiliationDepartment of Physiotherapy São Paulo State University (UNESP) Presidente Prudente
dc.description.affiliationDepartment of Physiotherapy State University of North of Parana (UENP) Jacarezinho
dc.description.affiliationPulmonary Division Heart Institute University of São Paulo Medical School
dc.description.affiliationDepartment of Physiotherapy The University of Western São Paulo Presidente Prudente
dc.description.affiliationUnespDepartment of Physiotherapy São Paulo State University (UNESP) Presidente Prudente
dc.format.extent273-279
dc.identifierhttp://dx.doi.org/10.1016/j.rppnen.2017.04.003
dc.identifier.citationRevista Portuguesa de Pneumologia (English Edition), v. 23, n. 5, p. 273-279, 2017.
dc.identifier.doi10.1016/j.rppnen.2017.04.003
dc.identifier.file2-s2.0-85032879254.pdf
dc.identifier.issn2173-5115
dc.identifier.scopus2-s2.0-85032879254
dc.identifier.urihttp://hdl.handle.net/11449/175433
dc.language.isoeng
dc.relation.ispartofRevista Portuguesa de Pneumologia (English Edition)
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAir pollution
dc.subjectCOPD
dc.subjectInterleukins
dc.subjectLung
dc.subjectPulmonary inflammatory markers
dc.subjectSpirometry
dc.titleEffects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPDen
dc.typeArtigo

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