Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution

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dc.contributor.authorRuiz, Thalles Fernando Rocha [UNESP]
dc.contributor.authorLeonel, Ellen Cristina Rivas [UNESP]
dc.contributor.authorColleta, Simone Jacovaci [UNESP]
dc.contributor.authorBedolo, Carolina Marques [UNESP]
dc.contributor.authorPegorin de Campos, Silvana Gisele [UNESP]
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2022-05-01T11:23:35Z
dc.date.available2022-05-01T11:23:35Z
dc.date.issued2022-01-01
dc.description.abstractIn the mammary gland (MG), the developmental window for gestational/lactational differentiation and growth is highly vulnerable to hormonal disruption. Here we describe that the MG involution process in female gerbil mothers is delayed by bisphenol A (BPA) exposure during gestation and lactation. The process is directly influenced by changes in expression of extracellular matrix proteases MMP-2, MMP-9, and FAP, and the incidence of collagen and elastin is reduced after 7 and 14 days of weaning. A pro-inflammatory environment in the late involution process was confirmed by higher expression of TNF-α, COX-2 and phospho-STAT3 n the MG stroma, allied to increases in the incidence of macrophages and mast cells. These aspects impacted the proliferative pattern of epithelial cells, which decreased on the 14th post-weaning day. These data confirm that the milk production window of susceptibility is vulnerable to the impact of BPA, which promotes a suggestive pro-tumoral microenvironment during mammary involution.en
dc.description.affiliationDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265, Jardim Nazareth
dc.description.affiliationDepartment of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás (UFG), Avenida Esperança, s/n, Câmpus Samambaia
dc.description.affiliationUnespDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265, Jardim Nazareth
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2018/23383–6
dc.description.sponsorshipIdFAPESP: 2020/01240–9
dc.description.sponsorshipIdCNPq: 302938/2020/6
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2021.103785
dc.identifier.citationEnvironmental Toxicology and Pharmacology, v. 89.
dc.identifier.doi10.1016/j.etap.2021.103785
dc.identifier.issn1872-7077
dc.identifier.issn1382-6689
dc.identifier.scopus2-s2.0-85121135281
dc.identifier.urihttp://hdl.handle.net/11449/233894
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.sourceScopus
dc.subjectBisphenol A
dc.subjectEndocrine disruptor
dc.subjectEstradiol
dc.subjectExtracellular matrix
dc.subjectInflammation
dc.titleGestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involutionen
dc.typeArtigo

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