Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration

dc.contributor.authorde Moura, Nayara Koba
dc.contributor.authorMartins, Eduardo Ferreira
dc.contributor.authorOliveira, Rodrigo Luiz Moraes Saldanha
dc.contributor.authorde Brito Siqueira, Idália Aparecida Waltrick
dc.contributor.authorMachado, João Paulo Barros
dc.contributor.authorEsposito, Elisa
dc.contributor.authorAmaral, Suelen Simões [UNESP]
dc.contributor.authorde Vasconcellos, Luana Marotta Reis [UNESP]
dc.contributor.authorPassador, Fabio Roberto
dc.contributor.authorde Sousa Trichês, Eliandra
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNational Institute for Space Research (INPE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.abstractPolymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3–11 μm) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR.en
dc.description.affiliationFederal University of São Paulo (UNIFESP), 330 Talim St
dc.description.affiliationNational Institute for Space Research (INPE), 1758 dos Astronautas Avenue
dc.description.affiliationSão Paulo State University (UNESP) Institute of Science and Technology, 777 Eng. Francisco José Longo Avenue
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Science and Technology, 777 Eng. Francisco José Longo Avenue
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2015/24659-7
dc.description.sponsorshipIdCNPq: 23637/2017-1
dc.description.sponsorshipIdCNPq: 310196/2018-3
dc.description.sponsorshipIdCNPq: 405675/2018-6
dc.identifier.citationMaterials Science and Engineering C, v. 117.
dc.relation.ispartofMaterials Science and Engineering C
dc.subjectCarbon nanotubes
dc.subjectPoly (lactic acid)
dc.titleSynergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regenerationen