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Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63

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dc.contributor.authorGubiani, Juliana R.
dc.contributor.authorOliveira, Michele C. S.
dc.contributor.authorNeponuceno, Ricardo A. R.
dc.contributor.authorCamargo, Maria J.
dc.contributor.authorGarcez, Walmir S.
dc.contributor.authorBiz, Andressa R.
dc.contributor.authorSoares, Marcos A.
dc.contributor.authorAraujo, Angela R. [UNESP]
dc.contributor.authorBolzani, Vanderlan da S. [UNESP]
dc.contributor.authorLisboa, Helen C. F.
dc.contributor.authorSousa Jr, Paulo T. de
dc.contributor.authorVasconcelos, Leonardo G. de
dc.contributor.authorRibeiro, Tereza A. N.
dc.contributor.authorOliveira, Juliana M. de
dc.contributor.authorBanzato, Thais P.
dc.contributor.authorLima, Carolina A.
dc.contributor.authorLongato, Giovanna B.
dc.contributor.authorBatista Jr, Joao M.
dc.contributor.authorBerlinck, Roberto G. S.
dc.contributor.authorTeles, Helder L.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionInst Fed Mato Grosso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2019-10-04T12:39:55Z
dc.date.available2019-10-04T12:39:55Z
dc.date.issued2019-08-01
dc.description.abstractPrenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines.en
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Dept Quim, Inst Ciencias Exatas & Terra, BR-78060900 Cuiaba, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Dept Biol, Inst Ciencias Exatas & Nat, Campus Rondonopolis, BR-78735901 Rondonopolis, MT, Brazil
dc.description.affiliationInst Fed Mato Grosso, BR-78721520 Rondonopolis, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso do Sul, Inst Quim, BR-79070900 Campo Grande, MS, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Biociencias, BR-78060900 Cuiaba, MT, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Nuleo Bioensaios Biossintese & Ecofisiol Prod Nat, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Dept Enfermagem, Campus Rondonopolis, BR-78735901 Rondonopolis, MT, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biol Func & Estrutural, BR-13083865 Campinas, SP, Brazil
dc.description.affiliationUniv Sao Francisco, Lab Pesquisa Biol Celular & Mol Tumores & Compost, BR-12916900 Braganca Paulista, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Nuleo Bioensaios Biossintese & Ecofisiol Prod Nat, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNational Institute of Science and Technology (INCT BioNat), Brazil
dc.description.sponsorshipNational Institute of Science and Technology (INCT Areas Umidas), Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCentre for Scientific Computing (NCC/GridUNESP) of Sao Paulo State University (UNESP)
dc.description.sponsorshipIdNational Institute of Science and Technology (INCT BioNat), Brazil: 465637/2014-0
dc.description.sponsorshipIdNational Institute of Science and Technology (INCT Areas Umidas), Brazil: 421733/2017-9
dc.description.sponsorshipIdFAPESP: 2013/50228-8
dc.description.sponsorshipIdFAPESP: 2014/25222-9
dc.format.extent162-167
dc.identifierhttp://dx.doi.org/10.1016/j.phytol.2019.06.003
dc.identifier.citationPhytochemistry Letters. Amsterdam: Elsevier, v. 32, p. 162-167, 2019.
dc.identifier.doi10.1016/j.phytol.2019.06.003
dc.identifier.issn1874-3900
dc.identifier.urihttp://hdl.handle.net/11449/185935
dc.identifier.wosWOS:000476725000031
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhytochemistry Letters
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPrenylated indole alkaloid
dc.subjectFungal alkaloid
dc.subjectEndophytic fungus
dc.subjectAspergillus terreus
dc.titleCytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0037579054083160[8]
unesp.author.orcid0000-0003-0118-2523[19]
unesp.author.orcid0000-0001-7616-9652[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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