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Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?

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dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorDe Paula E Silva, Ana Carolina Alves [UNESP]
dc.contributor.authorDe Oliveira, Haroldo Cesar [UNESP]
dc.contributor.authorMarcos, Caroline Maria [UNESP]
dc.contributor.authorDe Lacorte Singulani, Junya [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:19:40Z
dc.date.available2018-12-11T17:19:40Z
dc.date.issued2018-01-01
dc.description.abstractParacoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioidesspp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion.en
dc.description.affiliationLaboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú, Km 1
dc.description.affiliationUnespLaboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú, Km 1
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/10917-9
dc.description.sponsorshipIdFAPESP: 2014/10446-9
dc.description.sponsorshipIdFAPESP: 2015/03700-9
dc.description.sponsorshipIdFAPESP: 2015/14023-8
dc.description.sponsorshipIdFAPESP: 2016/17048-4
dc.format.extent374-377
dc.identifierhttp://dx.doi.org/10.1093/mmy/myx045
dc.identifier.citationMedical Mycology, v. 56, n. 3, p. 374-377, 2018.
dc.identifier.doi10.1093/mmy/myx045
dc.identifier.file2-s2.0-85045927323.pdf
dc.identifier.issn1460-2709
dc.identifier.issn1369-3786
dc.identifier.scopus2-s2.0-85045927323
dc.identifier.urihttp://hdl.handle.net/11449/176220
dc.language.isoeng
dc.relation.ispartofMedical Mycology
dc.relation.ispartofsjr0,973
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAdhesins
dc.subjectFungal-host cell interaction
dc.subjectGalleria mellonella
dc.subjectMice
dc.subjectParacoccidioides brasiliensis
dc.subjectVirulence factors
dc.titleCan passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?en
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
unesp.author.lattes3716273524139678[6]
unesp.author.orcid0000-0002-2115-8988[6]
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas