Properties and in vivo investigation of nanocrystalline hydroxyapatite obtained by mechanical alloying

dc.contributor.authorSilva, C. C.
dc.contributor.authorPinheiro, A. G.
dc.contributor.authorde Oliveira, R. S.
dc.contributor.authorGoes, J. C.
dc.contributor.authorAranha, N.
dc.contributor.authorde Oliveira, L. R.
dc.contributor.authorSombra, ASB
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ribeirao Preto
dc.date.accessioned2014-05-20T15:25:48Z
dc.date.available2014-05-20T15:25:48Z
dc.date.issued2004-06-01
dc.description.abstractMechanical alloying has been used successfully to produce nanocrystalline powders of hydroxyapatite (HA) using three different procedures. The milled HA was studied by X-ray diffraction, Infrared, Raman scattering spectroscopy and Scanning Electron Microscopy (SEM). We obtained HA with different degrees of crystallinity and time of milling. The grain size analysis through SEM and XRD shows particles with dimensions of 36.9, 14.3 and 35.5 nm (for (R1), (R2) and (R3), respectively) forming bigger units with dimensions given by 117.2, 110.8 and 154.4 nm (for (R1), (R2) and (R3), respectively). The Energy-Dispersive Spectroscopy (EDS) analysis showed that an atomic ratio of Ca/P= 1.67, 1.83 and 1.50 for reactions (R1), (R2) and (R3), respectively. These results suggest that the R1 nanocrystalline ceramic is closer to the expected value for the ratio Ca/P for hydroxyapatite, which is 513 congruent to 1.67. The bioactivity analysis shows that all the samples implanted into the rabbits can be considered biocompatible, since they had been considered not toxic, bad not caused inflammation and reject on the part of the organisms of the animals, during the period of implantation. The samples implanted in rabbits had presented new osseous tissue formation with the presence of osteoblasts cells. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Ceara, Dept Fis, Lab Telecomunicac & Ciência & Engn Mat, LOCEM, BR-60445760 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Quim Organ & Inorgan, BR-60445760 Fortaleza, Ceara, Brazil
dc.description.affiliationUNESP, Inst Quim, Araraquara, Brazil
dc.description.affiliationUniv Ribeirao Preto, UNAERP, Ribeirao Preto, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Araraquara, Brazil
dc.format.extent549-554
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2004.02.004
dc.identifier.citationMaterials Science & Engineering C-biomimetic and Supramolecular Systems. Amsterdam: Elsevier B.V., v. 24, n. 4, p. 549-554, 2004.
dc.identifier.doi10.1016/j.msec.2004.02.004
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/11449/36138
dc.identifier.wosWOS:000221992700015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaterials Science & Engineering C-biomimetic and Supramolecular Systems
dc.relation.ispartofjcr5.080
dc.relation.ispartofsjr1,110
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectinvestigationpt
dc.subjectnanocrystalline hydroxyapatitept
dc.subjectmechanical alloyingpt
dc.titleProperties and in vivo investigation of nanocrystalline hydroxyapatite obtained by mechanical alloyingen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6324-7647[4]
unesp.author.orcid0000-0003-1954-377X[5]
unesp.author.orcid0000-0001-5457-6484[2]

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