Ruthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosis

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dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorPoelhsitz, Gustavo V.
dc.contributor.authorBarbosa, Marilia I. F.
dc.contributor.authorLeite, Sergio R. A. [UNESP]
dc.contributor.authorBatista, Alzir A.
dc.contributor.authorEllena, Javier
dc.contributor.authorSato, Leticia S. [UNESP]
dc.contributor.authorFranzblau, Scott G.
dc.contributor.authorMoreno, Virtudes
dc.contributor.authorGambino, Dinorah
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Illinois
dc.contributor.institutionUniv Barcelona
dc.contributor.institutionUniv Republica
dc.date.accessioned2014-05-20T13:24:17Z
dc.date.available2014-05-20T13:24:17Z
dc.date.issued2011-10-01
dc.description.abstractThis paper describes the synthesis and characterization of four new ruthenium complexes containing 1,4 bis(diphenylphosphino)butane (dppb), 2-pyridinecarboxylic acid anion (pic) and the diimines [(2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (Me-bipy), 4,4'-dichloro-2,2'-bipyridine (Cl-bipy) and 1,10-phenanthroline (phen) as ligands, with formulae [Ru(pic)(dppb)(bipy)]PF6 (SCAR01), [Ru(pic)(dppb) (Me-bipy)]PF6 (SCAR02), [Ru(Pic)(dPPb)(Cl-bipy]PF6 (SCAR03) and [Ru(pic)(dppb)(phen)]PF6 (SCAR04). Additionally, the in vitro anti-Mycobacterium tuberculosis (MTB) activity, cytotoxicity and activity against in vitro infection of these complexes and two more complexes, cis-[Ru(pic)(dppe)(2)]PF6(SCAR05) and cis-[RuCl2(dppb)(bipy)] (SCAR06), and their free ligands are described and discussed. All compounds showed excellent MIC against MTB, low cytotoxicity and a selectivity index higher than 10. Also, all compounds showed significant intracellular inhibition and the compound SCAR05 showed a better activity than rifampin and SQ109. This is the first report of activity against in vitro infection of ruthenium compounds. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de Uberlândia (UFU), Inst Quim, BR-38400902 Uberlandia, MG, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Fis São Carlos, BR-13560970 São Carlos, SP, Brazil
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA
dc.description.affiliationUniv Barcelona, Dept Quim Inorgan, E-08028 Barcelona, Spain
dc.description.affiliationUniv Republica, Fac Quim, Catedra Quim Inorgan, Dept Estrella Campos, Montevideo 11800, Uruguay
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCYTED network RIIDFCM
dc.description.sponsorshipIdFAPESP: 08/10390-2
dc.description.sponsorshipIdFAPESP: 09/06499-1
dc.format.extent5099-5107
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2011.08.023
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 46, n. 10, p. 5099-5107, 2011.
dc.identifier.doi10.1016/j.ejmech.2011.08.023
dc.identifier.issn0223-5234
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/7486
dc.identifier.wosWOS:000296041600033
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.ispartofjcr4.816
dc.relation.ispartofsjr1,266
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosisen
dc.subjectDrug resistanceen
dc.subjectRutheniumen
dc.subjectPhosphine/diimine/picolinateen
dc.titleRuthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0002-0676-3098[6]
unesp.author.orcid0000-0002-6969-3963[1]
unesp.author.orcid0000-0003-1329-2260[2]
unesp.author.orcid0000-0002-8698-0243[8]
unesp.author.orcid0000-0001-9875-545X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas