Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

Chagas Vinhote, Juliana Freire; Lima, Danya Bandeira; Pessoa Bezerra de Menezes, Ramon Roseo Paula; Mello, Clarissa Perdigao; Souza, Bibiana Monson de [UNESP]; Havt, Alexandre; Palma, Mario Sergio [UNESP]; Santos, Ricardo Pires dos; Albuquerque, Eudenilson Lins de; Freire, Valder Nogueira; Costa Martins, Alice Maria

Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

Arquivos

WOS000411542300025.pdf (786.05 KB)

Data

2017-10-01

Autores

Chagas Vinhote, Juliana Freire

Lima, Danya Bandeira

Pessoa Bezerra de Menezes, Ramon Roseo Paula

Mello, Clarissa Perdigao

Souza, Bibiana Monson de

Havt, Alexandre

Palma, Mario Sergio

Santos, Ricardo Pires dos

Albuquerque, Eudenilson Lins de

Freire, Valder Nogueira

Editor

Elsevier B.V.

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.