Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

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dc.contributor.authorChagas Vinhote, Juliana Freire
dc.contributor.authorLima, Danya Bandeira
dc.contributor.authorPessoa Bezerra de Menezes, Ramon Roseo Paula
dc.contributor.authorMello, Clarissa Perdigao
dc.contributor.authorSouza, Bibiana Monson de [UNESP]
dc.contributor.authorHavt, Alexandre
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorSantos, Ricardo Pires dos
dc.contributor.authorAlbuquerque, Eudenilson Lins de
dc.contributor.authorFreire, Valder Nogueira
dc.contributor.authorCosta Martins, Alice Maria
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.date.accessioned2018-11-28T21:36:47Z
dc.date.available2018-11-28T21:36:47Z
dc.date.issued2017-10-01
dc.description.abstractChagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Clin & Toxicol Anal, Fortaleza, Ceara, Brazil
dc.description.affiliationSao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Ceara, Comp Engn, Sobral, Ceara, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Natal, RN, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFUNCAP
dc.description.sponsorshipIdCNPq: 151182/2013-2
dc.description.sponsorshipIdCNPq: 447592/2014-9
dc.format.extent168-172
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2017.08.002
dc.identifier.citationToxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
dc.identifier.doi10.1016/j.toxicon.2017.08.002
dc.identifier.fileWOS000411542300025.pdf
dc.identifier.issn0041-0101
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/165808
dc.identifier.wosWOS:000411542300025
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntiparasitic agents
dc.subjectMolecular docking
dc.subjectWasp venom
dc.subjectMastoparan
dc.titleTrypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDHen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0002-4546-2976[6]

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Artigos - Biologia - IBRC