Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
dc.contributor.author | Chagas Vinhote, Juliana Freire | |
dc.contributor.author | Lima, Danya Bandeira | |
dc.contributor.author | Pessoa Bezerra de Menezes, Ramon Roseo Paula | |
dc.contributor.author | Mello, Clarissa Perdigao | |
dc.contributor.author | Souza, Bibiana Monson de [UNESP] | |
dc.contributor.author | Havt, Alexandre | |
dc.contributor.author | Palma, Mario Sergio [UNESP] | |
dc.contributor.author | Santos, Ricardo Pires dos | |
dc.contributor.author | Albuquerque, Eudenilson Lins de | |
dc.contributor.author | Freire, Valder Nogueira | |
dc.contributor.author | Costa Martins, Alice Maria | |
dc.contributor.institution | Univ Fed Ceara | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Univ Fed Rio Grande do Norte | |
dc.date.accessioned | 2018-11-28T21:36:47Z | |
dc.date.available | 2018-11-28T21:36:47Z | |
dc.date.issued | 2017-10-01 | |
dc.description.abstract | Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved. | en |
dc.description.affiliation | Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil | |
dc.description.affiliation | Univ Fed Ceara, Dept Clin & Toxicol Anal, Fortaleza, Ceara, Brazil | |
dc.description.affiliation | Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Fed Ceara, Comp Engn, Sobral, Ceara, Brazil | |
dc.description.affiliation | Univ Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Natal, RN, Brazil | |
dc.description.affiliation | Univ Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil | |
dc.description.affiliationUnesp | Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | FUNCAP | |
dc.description.sponsorshipId | CNPq: 151182/2013-2 | |
dc.description.sponsorshipId | CNPq: 447592/2014-9 | |
dc.format.extent | 168-172 | |
dc.identifier | http://dx.doi.org/10.1016/j.toxicon.2017.08.002 | |
dc.identifier.citation | Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017. | |
dc.identifier.doi | 10.1016/j.toxicon.2017.08.002 | |
dc.identifier.file | WOS000411542300025.pdf | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.lattes | 2901888624506535 | |
dc.identifier.uri | http://hdl.handle.net/11449/165808 | |
dc.identifier.wos | WOS:000411542300025 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Toxicon | |
dc.relation.ispartofsjr | 0,692 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Antiparasitic agents | |
dc.subject | Molecular docking | |
dc.subject | Wasp venom | |
dc.subject | Mastoparan | |
dc.title | Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 2901888624506535 | |
unesp.author.orcid | 0000-0002-4546-2976[6] |
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