Renal lesions in leprosy: A retrospective study of 199 autopsies

dc.contributor.authorNakayama, E. E.
dc.contributor.authorUra, S.
dc.contributor.authorFleury, R. N.
dc.contributor.authorSoares, V
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Laura Souza
dc.description.abstractIn the present work, 199 patients with leprosy who underwent autopsy between 1970 and 1986 were retrospectively studied to determine the prevalence, types, clinical characteristics, and etiologic factors of renal lesions (RLs) in leprosy. Patients were divided into two groups: 144 patients with RLs (RL+) and 55 patients without RLs (RL-), RLs observed in 72% of the autopsied patients were amyloidosis (AMY) in 61 patients (31%), glomerulonephritis (GN) in 29 patients (14%), nephrosclerosis (NPS) in 22 patients (11%), tubulointerstitial nephritis (TIN) in 18 patients (9%), granuloma in 2 patients (1%), and other lesions in 12 patients (6%), AMY occurred most frequently in patients with lepromatous leprosy (36%; nonlepromatous leprosy, 5%; P < 0.01), recurrent erythema nodosum leprosum (33%; P < 0.02), and trophic ulcers (27%; 0.05 < P < 0.10), Ninety-seven percent of AMY was found in patients with lepromatous leprosy, 88% showed recurrent trophic ulcers, and 76% presented with erythema nodosum leprosum, NPS was found in older patients with arterial hypertension, neoplastic diseases, infectious diseases, and vasculitis associated with GN, Most patients with AMY presented with proteinuria (95%) and renal failure (88%), the most frequent causes of death were renal failure in patients with AMY (57%), infectious diseases in patients with GN (41%) and TIN (45%), and cardiovascular diseases in patients with NPS (41%), No difference in survival rates was observed among RL- patients and those with AMY, GN, NPS, or TIN. (C) 2001 by the National Kidney Foundation, Inc.en
dc.description.affiliationUNESP, Sch Med, Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationInst Laura Souza, Lima, Bauru, Peru
dc.description.affiliationUnespUNESP, Sch Med, Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.identifier.citationAmerican Journal of Kidney Diseases. Philadelphia: W B Saunders Co, v. 38, n. 1, p. 26-30, 2001.
dc.publisherW B Saunders Co
dc.relation.ispartofAmerican Journal of Kidney Diseases
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectrenal lesion (RL)pt
dc.subjectHansen's diseasept
dc.subjectrenal lesions (RLs)pt
dc.subjectamyloidosis (AMY)pt
dc.subjectglomerulonephritis (GN)pt
dc.subjectnephrosclerosis (NPS)pt
dc.titleRenal lesions in leprosy: A retrospective study of 199 autopsiesen
dcterms.rightsHolderW B Saunders Co
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt


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