Experimental pathogenicity of Candida albicans and Candida dubliniensis with continuous and discontinuous fringes morphotypes

dc.contributor.authorVasconcellos, Thassia Castro de [UNESP]
dc.contributor.authorKomiyama, Edson Yukio [UNESP]
dc.contributor.authorCardoso Jorge, Antonio Olavo [UNESP]
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.authorVidotto, Valerio
dc.contributor.authorKoga-Ito, Cristiane Yumi
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Turin
dc.date.accessioned2014-05-20T14:04:34Z
dc.date.available2014-05-20T14:04:34Z
dc.date.issued2011-07-01
dc.description.abstractA possible correlation between the presence of discontinuous fringes and high virulence has been previously suggested. The aim of this study was to compare the pathogenicity of Candida albicans and Candida dubliniensis with continuous and discontinuous fringes morphotypes on mice. For C. albicans, two discontinuous fringe morphotype isolates (PN 69, PN 74), two continuous fringe morphotype isolates (N 60, N 33) and one reference strain were used. For C. dubliniensis, three discontinuous fringe morphotype isolates (97487, 97464, 97519), two continuous fringe morphotype isolates (97040, 98026) and one reference strain were used. Swiss male mice were inoculated with a standardised suspension of the microorganisms and observed for 35 days. The pathogenicity of the isolates was analysed according to parameters proposed previously. Three isolates were considered pathogenic: PN 74, N 60 and 98026. Strain N 60 killed the highest amount of mice (80%). Animals inoculated with C. albicans did not show differences on survival estimate. Candida dubliniensis 98026 was more pathogenic than samples 97464 and 97519. on the other hand, the sample 97487 showed a higher pathogenicity when compared with 97040 (Kaplan-Meier test, P = 0.008). Strains with continuous fringe morphotypes were also associated with Candida sp. virulence in vivo.en
dc.description.affiliationSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil
dc.description.affiliationUniv Turin, Clin Microbiol Sect, Dept Med & Surg Sci, Turin, Italy
dc.description.affiliationUnespSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil
dc.format.extentE163-E167
dc.identifierhttp://dx.doi.org/10.1111/j.1439-0507.2010.01865.x
dc.identifier.citationMycoses. Malden: Wiley-blackwell, v. 54, n. 4, p. E163-E167, 2011.
dc.identifier.doi10.1111/j.1439-0507.2010.01865.x
dc.identifier.issn0933-7407
dc.identifier.lattes0053567153623569
dc.identifier.lattes6065636367717382
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-4470-5171
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.urihttp://hdl.handle.net/11449/22653
dc.identifier.wosWOS:000292501600023
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMycoses
dc.relation.ispartofjcr2.793
dc.relation.ispartofsjr1,069
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCandidaen
dc.subjectmycological typing techniquesen
dc.subjectvirulenceen
dc.titleExperimental pathogenicity of Candida albicans and Candida dubliniensis with continuous and discontinuous fringes morphotypesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes0053567153623569[3]
unesp.author.lattes6065636367717382[4]
unesp.author.lattes6543563161403421[6]
unesp.author.orcid0000-0002-1747-6158[3]
unesp.author.orcid0000-0002-4470-5171[4]
unesp.author.orcid0000-0002-2416-2173[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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