Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin
dc.contributor.author | Bonardi, Joao Paulo [UNESP] | |
dc.contributor.author | Pereira, Rodrigo dos Santos [UNESP] | |
dc.contributor.author | Jorge Boos Lima, Fernanda Brasil Daura | |
dc.contributor.author | Faverani, Leonardo Perez [UNESP] | |
dc.contributor.author | Griza, Geraldo Luiz [UNESP] | |
dc.contributor.author | Okamoto, Roberta [UNESP] | |
dc.contributor.author | Hochuli-Vieira, Eduardo [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | |
dc.date.accessioned | 2018-11-29T06:33:40Z | |
dc.date.available | 2018-11-29T06:33:40Z | |
dc.date.issued | 2018-02-01 | |
dc.description.abstract | Purpose: The aim of this study was to compare ChronOS (beta-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1: 1 ratio in human maxillary sinus bone augmentation. Materials and Methods: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1: 1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1: 1 ratio. The number of samples for each group was determined by the statistical power test. Results: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 mu m(2), respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P <.05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 mu m(2) in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P <.05). Areas of connective tissue were 67,829.0 +/- 22,984.6 mu m(2) in group 1, 97,445.9 +/- 18,983.3 mu m(2) in group 2, 88,256.0 +/- 21,820.5 mu m(2) in group 3, 65,501.8 +/- 6,297.6 in group 4, and 70,203.2 +/- 13,421.3 mu m(2) in group 5. Conclusions: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone. (C) 2017 American Association of Oral and Maxillofacial Surgeons | en |
dc.description.affiliation | Univ Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP, Brazil | |
dc.description.affiliation | Univ Fed Minas Gerais, Dept Clin Pathol & Surg, Belo Horizonte, MG, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 2012/08455-4 | |
dc.description.sponsorshipId | FAPESP: 2012/10028-7 | |
dc.format.extent | 325-335 | |
dc.identifier | http://dx.doi.org/10.1016/j.joms.2017.09.020 | |
dc.identifier.citation | Journal Of Oral And Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 76, n. 2, p. 325-335, 2018. | |
dc.identifier.doi | 10.1016/j.joms.2017.09.020 | |
dc.identifier.file | WOS000423459200017.pdf | |
dc.identifier.issn | 0278-2391 | |
dc.identifier.lattes | 1527011976590326 | |
dc.identifier.uri | http://hdl.handle.net/11449/165977 | |
dc.identifier.wos | WOS:000423459200017 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Journal Of Oral And Maxillofacial Surgery | |
dc.relation.ispartofsjr | 0,967 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.title | Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 1527011976590326 | |
unesp.author.lattes | 6853485483683678[7] | |
unesp.author.orcid | 0000-0002-6773-6966[6] | |
unesp.author.orcid | 0000-0003-4040-9313[7] |
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