The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons

dc.contributor.authorCruz Rodrigues, Kellen C. da
dc.contributor.authorPereira, Rodrigo M.
dc.contributor.authorCampos, Thais D. P. de
dc.contributor.authorMoura, Rodrigo F. de
dc.contributor.authorSilva, Adelino S. R. da
dc.contributor.authorCintra, Dennys E.
dc.contributor.authorRopelle, Eduardo R.
dc.contributor.authorPauli, Jose R.
dc.contributor.authorAraujo, Michel B. de
dc.contributor.authorMoura, Leandro P. de [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Catholic Ctr Quixada Unicatolica
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.abstractObesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling. On the other hand, stimulation of AgRP neurons suppresses WAT browning. The hypothalamic inflammatory process that occurs in obesity impairs insulin and leptin signaling in this tissue and, consequently, can decrease WAT browning. In addition, practicing physical exercise may be a great strategy for triggering the browning process since it reduces hypothalamic inflammation and increases POMC neurons gene expression. Moreover, physical exercise stimulates irisin gene expression, which has an important impact on thermogenesis, which in turn culminates in increased gene expression of proteins such as UCP-1 and Cidea, which are related to WAT browning. Furthermore, thermogenetic activation of WAT leads to increased energy expenditure, favoring obesity treatment. Therefore, this mini-review aimed to highlight the most recent studies that link the control of hypothalamic activity with the browning metabolism of adipose tissue in response to physical exercise.en
dc.description.affiliationUniv Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise, Limeira, Brazil
dc.description.affiliationUniv Fed Lavras, Dept Hlth Sci, Lavras, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Campinas, Sch Appl Sci, Lab Nutr Genom, Limeira, Brazil
dc.description.affiliationUniv Estadual Campinas, Sch Appl Sci, Ctr Res Sport Sci, Limeira, Brazil
dc.description.affiliationUniv Catholic Ctr Quixada Unicatolica, Quixada, Brazil
dc.description.affiliationSao Paulo State Univ, Postgrad Program Motr Sci, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Postgrad Program Motr Sci, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/07199-2
dc.description.sponsorshipIdFAPESP: 2016/24406-4
dc.identifier.citationFrontiers In Cellular Neuroscience. Lausanne: Frontiers Media Sa, v. 12, 7 p., 2018.
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Cellular Neuroscience
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectWAT browning
dc.subjectphysical exercise
dc.titleThe Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neuronsen
dcterms.rightsHolderFrontiers Media Sa
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