Expression patterns of CD56+and CD16+cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival

Página do item simplificado
dc.contributor.authorDos Santos, Daniela Cristina [UNESP]
dc.contributor.authorSaraiva Camara, Niels Olsen
dc.contributor.authorRibeiro David, Daisa Silva
dc.contributor.authorAvancini Costa Malheiros, Denise Maria
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-11-26T17:42:11Z
dc.date.available2018-11-26T17:42:11Z
dc.date.issued2017-12-01
dc.description.abstractBackgroundThe study investigated whether immunohistochemical features of interstitial and glomerular CD56 and CD16 infiltrates - NK cells markers - could be associated with microcirculation injury scores - peritubular capillaritis (ptc) and glomerulitis (g) - and graft survival. MethodsThe research analyzed the immunohistochemical pattern of CD56 and CD16 in interstitial and glomerular compartments of biopsies for-cause biopsies from 59 recipients diagnosed with acute rejection (mean=135.5days post-transplant). ResultsInterstitial CD56+ cells had an increased expression for glomerulitis (g1) (P=0.02) and peritubular capillaritis (ptc2) (P=0.003) presence. It was noted that interstitial CD56+cells with mean above 0.56cells/mm(2) had worse allograft survival. CD56+ cells in the interstitial compartment with mean less than or equal to 0.56cells/mm(2) was related with absence or mild peritubular capillaritis (P=0.012) and mean above 0.56cells/mm(2), respectively, with glomerulitis (P=0.002) presence. Interstitial CD16 cells showed greater positive results in relation to peritubular capillaritis (P=0.0001) cases. Similarly, it was observed that glomerular CD16+ cells had higher positive results in glomerulitis (P=0.009) presence. ConclusionsThe study findings showed that CD56+ cell infiltrated in the interstitial compartment was significantly associated with microcirculation injury scores, especially the glomerulitis, and graft survival. Summary at a Glance This study suggests that increased expression of interstitial natural killer cells in renal allograft biopsies of kidney transplant recipients with rejection may be associated with poorer graft outcomes.en
dc.description.affiliationSao Paulo State Univ, Dept Pathol, Coll Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Coll Med Univ, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Pathol, Coll Med, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/21604-9
dc.format.extent993-1001
dc.identifierhttp://dx.doi.org/10.1111/nep.12897
dc.identifier.citationNephrology. Hoboken: Wiley, v. 22, n. 12, p. 993-1001, 2017.
dc.identifier.doi10.1111/nep.12897
dc.identifier.issn1320-5358
dc.identifier.urihttp://hdl.handle.net/11449/163476
dc.identifier.wosWOS:000415374400009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofNephrology
dc.relation.ispartofsjr0,830
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectimmunostaining
dc.subjectmicrocirculation injury
dc.subjectNatural Killer cells
dc.subjectrenal allograft survival
dc.subjectrenal pathology
dc.subjecttransplant
dc.titleExpression patterns of CD56+and CD16+cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survivalen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

Arquivos

Coleções

Artigos - Patologia - FMB