Changes of metabolic and inflammatory markers in HIV infection: glucose, lipids, serum Hs-CRP and myeloperoxidase

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dc.contributor.authorKalva Borato, Danielle Cristyane
dc.contributor.authorParabocz, Gisele Chibinski
dc.contributor.authorWeber Ribas, Sonia Regina
dc.contributor.authorKalva-Filho, Carlos Augusto [UNESP]
dc.contributor.authorBorba, Luciana Maria
dc.contributor.authorSanches Ito, Carmen Antonia
dc.contributor.authorBail, Larissa
dc.contributor.authordos Santos, Fabio Andre
dc.contributor.authorRebuglio Vellosa, Jose Carlos
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.contributor.institutionEAS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:18Z
dc.date.available2014-05-20T13:23:18Z
dc.date.issued2012-10-01
dc.description.abstractObjective: HIV infection is exacerbated through additional pro-atherogenic mechanisms related to the processes of immune activation, inflammation, coagulation, and the modification of lipoproteins (e.g., particles of high density lipoprotein), contributing to increased cardiovascular risk. The aim of this study was to analyze the serum concentrations of myeloperoxidase (MPO) and other laboratory parameters in HIV-infected patients treated or not with antiretroviral drugs compared to non-infected individuals.Materials/Methods: The study included 154 volunteers: 47 non-infected individuals (control group - CON), 27 infected and untreated individuals (NTARv group) and 80 treated individuals (TARV group). We analyzed the counts of CD4+ lymphocytes and the viral load of the infected patients, along with the blood count, fasting glucose, total serum cholesterol (CHOL), HDL cholesterol, LDL cholesterol, triglycerides, MPO and high-sensitivity C-reactive protein (CRP) of all study participants.Results: There were significant increases in glucose, CHOL, LDL cholesterol, and triglycerides in the TARV group and significant reductions in the levels of HDL cholesterol for the TARV and NTARV groups. Significantly elevated levels of Hs-CRP were observed only in the TARV group, while levels of MPO were significantly higher in the TARV and NTARV groups compared to the control group. A correlation of MPO with Hs-CRP (r = 0.21, p = 0.032) was observed for HIV-infected patients, but MPO did not correlate significantly with the other analyzed parameters.Conclusions: The investigation of early biomarkers for cardiovascular risk evaluation, such as MPO, contributes to the clinical monitoring of HIV-infected individuals. The serum levels of MPO correlated with Hs-CRP and were high in HIV-infected individuals, indicating a possible predictor of cardiovascular events in these patients. (c) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationParana State Univ Ponta Grossa UEPG, Dept Clin & Toxicol Anal, Ponta Grossa, PR, Brazil
dc.description.affiliationEAS, Ponta Grossa, PR, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Fisioterapia, Presidente Prudente, SP, Brazil
dc.description.affiliationParana State Univ Ponta Grossa UEPG, Dept Dent, Ponta Grossa, PR, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Fisioterapia, Presidente Prudente, SP, Brazil
dc.description.sponsorshipFundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná (FAADCT/PR)
dc.format.extent1353-1360
dc.identifierhttp://dx.doi.org/10.1016/j.metabol.2012.03.003
dc.identifier.citationMetabolism-clinical and Experimental. Philadelphia: W B Saunders Co-elsevier Inc, v. 61, n. 10, p. 1353-1360, 2012.
dc.identifier.doi10.1016/j.metabol.2012.03.003
dc.identifier.issn0026-0495
dc.identifier.lattes6542042233451955
dc.identifier.urihttp://hdl.handle.net/11449/7005
dc.identifier.wosWOS:000309625900004
dc.language.isoeng
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofMetabolism-clinical and Experimental
dc.relation.ispartofjcr5.963
dc.relation.ispartofsjr2,285
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleChanges of metabolic and inflammatory markers in HIV infection: glucose, lipids, serum Hs-CRP and myeloperoxidaseen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co-elsevier Inc
unesp.author.lattes6542042233451955
unesp.author.orcid0000-0003-4747-9197[9]
unesp.author.orcid0000-0002-9987-6250[1]
unesp.author.orcid0000-0002-8511-9590[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentFisioterapia - FCTpt

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Presidente Prudente - FCT - Faculdade de Ciências e Tecnologia