Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities

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dc.contributor.authorSilva, Lucas Porangaba [UNESP]
dc.contributor.authorFortaleza, Carlos Magno Castelo Branco [UNESP]
dc.contributor.authorTeixeira, Nathalia Bibiana [UNESP]
dc.contributor.authorSilva, Luís Thadeo Poianas [UNESP]
dc.contributor.authorde Angelis, Carolina Destro [UNESP]
dc.contributor.authorRibeiro de Souza da Cunha, Maria de Lourdes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:28:05Z
dc.date.available2023-07-29T13:28:05Z
dc.date.issued2022-11-01
dc.description.abstractAt present, multidrug-resistant microorganisms are already responsible for community-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious public health risk worldwide because of the rapid spread and diversification of pandemic clones that are characterized by increasing virulence and antimicrobial resistance. The aim of this study was to identify the prevalence and factors associated with nasal, oral and rectal carriage of S. aureus and MRSA in bedridden patients and residents of long-term care facilities for the elderly (LTCFs) in Botucatu, SP, Brazil. Nasal, oral and rectal swab isolates obtained from 226 LTCF residents or home-bedridden patients between 2017 and 2018 were submitted to susceptibility testing, detection of the mecA gene, SCCmec characterization, and molecular typing by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Logistic regression analysis was used to identify risk factors associated with the presence of S. aureus and MRSA. The prevalence of S. aureus and MRSA was 33.6% (n = 76) and 8% (n = 18), respectively. At the nine LTCFs studied, the prevalence of S. aureus ranged from 16.6% to 85.7% and that of MRSA from 13.3% to 25%. Living in an LTCF, male gender, a history of surgeries, and a high Charlson Comorbidity Index score were risk factors associated with S. aureus carriage, while MRSA carriage was positively associated with male gender. This study showed a high prevalence of S. aureus among elderly residents of small (<15 residents) and medium-sized (15–49 residents) LTCFs and a higher prevalence of MRSA in the oropharynx.en
dc.description.affiliationDepartment of Chemical and Biological Sciences Biosciences Institute UNESP—Universidade Estadual Paulista, SP
dc.description.affiliationDepartment of Infectology Dermatology Diagnostic Imaging and Radiotherapy Botucatu School of Medicine UNESP—Universidade Estadual Paulista, SP
dc.description.affiliationUnespDepartment of Chemical and Biological Sciences Biosciences Institute UNESP—Universidade Estadual Paulista, SP
dc.description.affiliationUnespDepartment of Infectology Dermatology Diagnostic Imaging and Radiotherapy Botucatu School of Medicine UNESP—Universidade Estadual Paulista, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 303603
dc.identifierhttp://dx.doi.org/10.3390/antibiotics11111526
dc.identifier.citationAntibiotics, v. 11, n. 11, 2022.
dc.identifier.doi10.3390/antibiotics11111526
dc.identifier.issn2079-6382
dc.identifier.scopus2-s2.0-85141772166
dc.identifier.urihttp://hdl.handle.net/11449/247867
dc.language.isoeng
dc.relation.ispartofAntibiotics
dc.sourceScopus
dc.subjectbedridden patients
dc.subjectelderly population
dc.subjectlong-term care facility
dc.subjectmolecular epidemiology
dc.subjectMRSA
dc.subjectStaphylococcus aureus
dc.titleMolecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilitiesen
dc.typeArtigo
unesp.author.orcid0000-0002-4576-1546[1]
unesp.author.orcid0000-0001-9079-2723[6]

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