Melanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area

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dc.contributor.authorDias, Mirela B. [UNESP]
dc.contributor.authorGargaglioni, Luciane H [UNESP]
dc.contributor.authorPatrone, Luis G.A. [UNESP]
dc.contributor.authorRodrigues, LaĆ­sa TC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2022-06-20T18:14:40Z
dc.date.available2022-06-20T18:14:40Z
dc.date.issued2022
dc.descriptionMelanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation ( E), body temperature, EEG and EMG of unanesthetized male Wistar rats before and after microinjection of MCH [0.4 mM] into the LHA and LC, or the MCH1-R antagonist (SNAP-94847 [63 mM]), into the LHA, in room air and in 7% CO2 during wakefulness and sleep, in the dark and light periods. MCH intra-LHA caused a decreased CO2 ventilatory response during wakefulness and sleep, while SNAP-94847 intra-LHA increased this response, during wakefulness in the light period. In the LC, MCH or the MCH1-R antagonist caused no change in the hypercapnic ventilatory response. Our results suggest that MCH, in the LHA, exerts an inhibitory modulation of the hypercapnic ventilatory response during the light-inactive period in rats.pt
dc.description.sponsorshipFundaĆ§Ć£o de Amparo Ć  Pesquisa do Estado de SĆ£o Paulo (FAPESP)
dc.description.sponsorshipCoordenaĆ§Ć£o de AperfeiƧoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipIdFAPESP:2019/17693-5
dc.description.sponsorshipIdFAPESP: 2018/01781-0
dc.description.sponsorshipIdCAPES: 88887.194785/2018-00
dc.formatpdfpt
dc.identifier.lattes3203493045928389
dc.identifier.lattes5850453468994497
dc.identifier.lattes8833369074938340
dc.identifier.orcid0000-0002-4084-3139
dc.identifier.orcid0000-0002-8270-1892
dc.identifier.orcid0000-0003-4097-5286
dc.identifier.orcid0000-0003-3704-6099
dc.identifier.urihttp://hdl.handle.net/11449/235199
dc.language.isoeng
dc.rights.accessRightsAcesso aberto
dc.rights.holderExperimental Physiologypt
dc.subjectBreathingpt
dc.subjectChemoreceptorspt
dc.subjectHypothalamuspt
dc.subjectBreathingpt
dc.titleMelanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic areapt
dc.typeDado de pesquisa
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de BiociĆŖncias, Botucatupt

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