Melatonin-loaded nanocarriers: New horizons for therapeutic applications

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dc.contributor.authorChuffa, Luiz Gustavo de Almeida [UNESP]
dc.contributor.authorSeiva, Fábio Rodrigues Ferreira
dc.contributor.authorNovais, Adriana Alonso
dc.contributor.authorSimão, Vinícius Augusto [UNESP]
dc.contributor.authorMartín Giménez, Virna Margarita
dc.contributor.authorManucha, Walter
dc.contributor.authorZuccari, Debora Aparecida Pires de Campos
dc.contributor.authorReiter, Russel J.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionLuiz Meneghel Campus
dc.contributor.institutionUFMT
dc.contributor.institutionUniversidad Católica de Cuyo
dc.contributor.institutionUniversidad Nacional de Cuyo
dc.contributor.institutionConsejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET)
dc.contributor.institutionFAMERP
dc.contributor.institutionUT Health
dc.date.accessioned2022-05-01T05:29:34Z
dc.date.available2022-05-01T05:29:34Z
dc.date.issued2021-06-01
dc.description.abstractThe use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and nonmetallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.en
dc.description.affiliationDepartment of Structural and Functional Biology UNESP-São Paulo State University Institute of Biosciences
dc.description.affiliationDepartment of Biology Biological Science Center Universidade Estadual do Norte do Paraná-UENP Luiz Meneghel Campus
dc.description.affiliationHealth Sciences Institute Federal University of Mato Grosso UFMT
dc.description.affiliationInstituto de Investigaciones en Ciencias Químicas Facultad de Ciencias Químicas y Tecnológicas Universidad Católica de Cuyo
dc.description.affiliationLaboratorio de Farmacología Experimental Básica y Traslacional Área de Farmacología Departamento de Patología Facultad de Ciencias Médicas Universidad Nacional de Cuyo
dc.description.affiliationInstituto de Medicina y Biología Experimental de Cuyo Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET)
dc.description.affiliationDepartment of Molecular Biology Cancer Molecular Research Laboratory (LIMC) FAMERP
dc.description.affiliationDepartment of Cell Systems and Anatomy UT Health
dc.description.affiliationUnespDepartment of Structural and Functional Biology UNESP-São Paulo State University Institute of Biosciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2019/00906-6
dc.description.sponsorshipIdCNPq: 304108/2020-0
dc.identifierhttp://dx.doi.org/10.3390/molecules26123562
dc.identifier.citationMolecules, v. 26, n. 12, 2021.
dc.identifier.doi10.3390/molecules26123562
dc.identifier.issn1420-3049
dc.identifier.scopus2-s2.0-85108630871
dc.identifier.urihttp://hdl.handle.net/11449/233193
dc.language.isoeng
dc.relation.ispartofMolecules
dc.sourceScopus
dc.subjectDrug-delivery system
dc.subjectMelatonin
dc.subjectMelatonin-loaded nanocarriers
dc.subjectNanocarriers
dc.subjectNanoparticles
dc.titleMelatonin-loaded nanocarriers: New horizons for therapeutic applicationsen
dc.typeResenha

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Artigos - Anatomia - IBB