Antimicrobial use and incidence of multidrug-resistant Pseudomonas aeruginosa in a teaching hospital: an ecological approach

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dc.contributor.authordas Neves, Mariana Tresoldi [UNESP]
dc.contributor.authorPinto de Lorenzo, Mariana Eliza [UNESP]
dc.contributor.authorMonteiro Barros Almeida, Ricardo Augusto [UNESP]
dc.contributor.authorFortaleza, Carlos Magno Castelo Branco [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:34:30Z
dc.date.available2014-05-20T13:34:30Z
dc.date.issued2010-11-01
dc.description.abstractIntroduction: Multidrug-resistant Pseudomonas aeruginosa is a major threat in healthcare settings. The use of antimicrobials can influence the incidence of resistant strains by direct and indirect mechanisms. The latter can be addressed by ecological studies. Methods: Our group attempted to analyze the relation between the use of antipseudomonal drugs and the incidence of MDR-PA among 18 units from a 400-bed teaching hospital. The study had a retrospective, ecological design, comprising data from 2004 and 2005. Data on the use of four antimicrobials (amikacin, ciprofloxacin, ceftazidime and imipenem) were tested for correlation with the incidence of MDR-PA (defined as isolates resistant to the four antimicrobials of interest) in clinical cultures. Univariate and multivariate linear regression analyses were performed. Results: Significant correlations were determined between use and resistance for all antimicrobials in the univariate analysis: amikacin (standardized correlation coefficient = 0.73, p = 0.001); ciprofloxacin (0.71, p = 0.001); ceftazidime (0.61, p = 0.007) and imipenem (0.87, p < 0.001). In multivariate analysis, only imipenem (0.67, p = 0.01) was independently related to the incidence of multidrug-resistant strains. Conclusions: These findings share similarities with those reported in individual-based observational studies, with possible implications for infection control.en
dc.description.affiliationSão Paulo State Univ, Botucatu Sch Med, Dept Trop Dis, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Sch Med, Bauru State Hosp, Bauru, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Sch Med, Dept Trop Dis, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Sch Med, Bauru State Hosp, Bauru, SP, Brazil
dc.format.extent629-632
dc.identifierhttp://dx.doi.org/10.1590/S0037-86822010000600005
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 43, n. 6, p. 629-632, 2010.
dc.identifier.fileS0037-86822010000600005-en.pdf
dc.identifier.issn0037-8682
dc.identifier.scieloS0037-86822010000600005
dc.identifier.urihttp://hdl.handle.net/11449/11831
dc.identifier.wosWOS:000285513300005
dc.language.isoeng
dc.publisherSoc Brasileira Medicina Tropical
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.relation.ispartofjcr1.358
dc.relation.ispartofsjr0,658
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPseudomonas aeruginosaen
dc.subjectAntimicrobial resistanceen
dc.subjectEcological studyen
dc.titleAntimicrobial use and incidence of multidrug-resistant Pseudomonas aeruginosa in a teaching hospital: an ecological approachen
dc.title.alternativeUso de antimicrobianos e incidência de Pseudomonas aeruginosa multidroga-resistente em um hospital de ensino: uma abordagem ecológicapt
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Medicina Tropical
unesp.author.lattes2589937673452910[4]
unesp.author.orcid0000-0003-4120-1258[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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