New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers

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dc.contributor.authorLuiz, Marcela Tavares [UNESP]
dc.contributor.authordi Filippo, Leonardo Delello [UNESP]
dc.contributor.authorDutra, Jessyca Aparecida Paes [UNESP]
dc.contributor.authorViegas, Juliana Santos Rosa
dc.contributor.authorSilvestre, Amanda Letícia Polli [UNESP]
dc.contributor.authorAnselmi, Caroline [UNESP]
dc.contributor.authorDuarte, Jonatas Lobato [UNESP]
dc.contributor.authorCalixto, Giovana Maria Fioramonti [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade do Porto
dc.date.accessioned2023-07-29T16:10:15Z
dc.date.available2023-07-29T16:10:15Z
dc.date.issued2023-03-01
dc.description.abstractDental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the formation of cavities. The treatment of caries remains a global challenge and the development of effective drug delivery systems is a potential strategy. In this context, different drug delivery systems have been investigated to remove oral biofilms and remineralize dental enamel. For a successful application of these systems, it is necessary that they remain adhered to the surfaces of the teeth to allow enough time for the removal of biofilms and enamel remineralization, thus, the use of mucoadhesive systems is highly encouraged. Among the systems used for this purpose, liquid crystalline systems, polymer-based nanoparticles, lipid-based nanoparticles, and inorganic nanoparticles have demonstrated great potential for preventing and treating dental caries through their own antimicrobial and remineralization properties or through delivering drugs. Therefore, the present review addresses the main drug delivery systems investigated in the treatment and prevention of dental caries.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationInstituto de Investigação e Inovação em Saúde Universidade do Porto
dc.description.affiliationSchool of Dentistry São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespSchool of Dentistry São Paulo State University (UNESP), São Paulo
dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics15030762
dc.identifier.citationPharmaceutics, v. 15, n. 3, 2023.
dc.identifier.doi10.3390/pharmaceutics15030762
dc.identifier.issn1999-4923
dc.identifier.scopus2-s2.0-85151711294
dc.identifier.urihttp://hdl.handle.net/11449/249826
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.sourceScopus
dc.subjectbuccal administration
dc.subjectdrug delivery systems
dc.subjectnanotechnology
dc.subjectoral biofilm
dc.subjectremineralization
dc.titleNew Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriersen
dc.typeResenha
unesp.author.orcid0000-0001-6365-8756[2]
unesp.author.orcid0000-0002-8615-3758[4]
unesp.author.orcid0000-0003-1041-5835[8]
unesp.author.orcid0000-0002-6698-0545[9]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas