Extrahepatic cholangiocarcinoma in an adult Black Howler Monkey (Primates: Atelidae)
dc.contributor.author | De Santi, Mariele [UNESP] | |
dc.contributor.author | Do Couto, Caroline [UNESP] | |
dc.contributor.author | Montanhim, Gabriel Luiz [UNESP] | |
dc.contributor.author | Moraes, Paola Castro [UNESP] | |
dc.contributor.author | Bertolo, Paulo Henrique Leal [UNESP] | |
dc.contributor.author | De Oliveira Vasconcelos, Rosemeri [UNESP] | |
dc.contributor.author | Coutinho, Acácia Rebello [UNESP] | |
dc.contributor.author | Werther, Karin [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2020-12-12T01:49:09Z | |
dc.date.available | 2020-12-12T01:49:09Z | |
dc.date.issued | 2019-01-01 | |
dc.description.abstract | Over the past years, the number of cases of neoplasms reported in nonhuman primates has increased considerably, with hepatocellular tumors observed in several species. Here, a case of extrahepatic cholangiocarcinoma in an adult male Black Howler Monkey (Alouatta caraya) is presented. The animal, kept as a pet, was admitted to the Veterinary Hospital with clinical signs of cholestasis. After unsuccessful medical treatment, the animal was submitted to a cholecystoduodenostomy. During the surgical procedure, the hepatobiliary system was meticulously observed. The liver showed no macroscopic alterations; however, there was a solid mass throughout the common bile duct. Biopsy specimens were collected from the bile duct mass, liver, and gallbladder for histological and immunohistochemical evaluation. Histological examination of the liver showed diffuse accentuated vacuolization and necrosis, besides hemosiderin accumulation inside hepatocytes. In the portal region, there was an accentuated proliferation of biliary ducts, which were replete with bilirubin. Discrete, neutrophilic, inflammatory infiltrates and fibrosis were also observed. The bile duct mass showed a cellular proliferation of epithelial origin, confirmed on immunohistochemical analysis. The arrangement, characteristics, and growth pattern of these cells revealed a malignant neoplasm. Despite the success of the procedure, the animal died hours later. Cholangiocarcinoma generally presents with a high mortality rate, since its late clinical presentation makes therapy ineffective due to its large extension at the time of diagnosis. The owner did not allow a necropsy; therefore, the presence of other neoplasms and important organ alterations, which may be aggravated the patient's clinical condition, were not confirmed. | en |
dc.description.affiliation | Programa de Pós-graduação em Medicina Veterinária - PPGMV Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP Campus Jaboticabal, Via de Acesso Prof.Paulo Donato Castellane s/n | |
dc.description.affiliation | Prog. de Residencia Multiprofissional em Area Profissional da Saude - Medicina de Animais Selvagens Universidade Estadual Paulista - UNESP | |
dc.description.affiliation | Programa de Pós-graduação em Cirurgia Veterinária Departamento de Clínica e Cirurgia Veterinária - DCCV Universidade Estadual Paulista - UNESP | |
dc.description.affiliation | Departamento de Clínica e Cirurgia Veterinária - DCCV Universidade Estadual Paulista - UNESP | |
dc.description.affiliation | Laboratório de Imunopatologia Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP | |
dc.description.affiliation | Programa de Aprimoramento Profissional em Medicina Veterinaria - Diagnostico Por Imagem Universidade Estadual Paulista - UNESP | |
dc.description.affiliation | Laboratório de Patologia de Animais Selvagens Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Programa de Pós-graduação em Medicina Veterinária - PPGMV Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP Campus Jaboticabal, Via de Acesso Prof.Paulo Donato Castellane s/n | |
dc.description.affiliationUnesp | Prog. de Residencia Multiprofissional em Area Profissional da Saude - Medicina de Animais Selvagens Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Programa de Pós-graduação em Cirurgia Veterinária Departamento de Clínica e Cirurgia Veterinária - DCCV Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Departamento de Clínica e Cirurgia Veterinária - DCCV Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Laboratório de Imunopatologia Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Programa de Aprimoramento Profissional em Medicina Veterinaria - Diagnostico Por Imagem Universidade Estadual Paulista - UNESP | |
dc.description.affiliationUnesp | Laboratório de Patologia de Animais Selvagens Departamento de Patologia Veterinária - DPV Universidade Estadual Paulista - UNESP | |
dc.identifier | http://dx.doi.org/10.29374/2527-2179.bjvm101519 | |
dc.identifier.citation | Revista Brasileira de Medicina Veterinaria, v. 41. | |
dc.identifier.doi | 10.29374/2527-2179.bjvm101519 | |
dc.identifier.issn | 2527-2179 | |
dc.identifier.issn | 0100-2430 | |
dc.identifier.lattes | 9956383349362446 | |
dc.identifier.orcid | 0000-0002-0255-2971 | |
dc.identifier.scopus | 2-s2.0-85076160316 | |
dc.identifier.uri | http://hdl.handle.net/11449/199780 | |
dc.language.iso | eng | |
dc.relation.ispartof | Revista Brasileira de Medicina Veterinaria | |
dc.source | Scopus | |
dc.subject | Alouatta caraya | |
dc.subject | Cholecystoenterostomy | |
dc.subject | Histopathology | |
dc.subject | Immunohistochemistry | |
dc.subject | Neoplasm | |
dc.title | Extrahepatic cholangiocarcinoma in an adult Black Howler Monkey (Primates: Atelidae) | en |
dc.type | Resenha | |
unesp.author.lattes | 9956383349362446[4] | |
unesp.author.orcid | 0000-0002-0255-2971[4] | |
unesp.department | Patologia Veterinária - FCAV | pt |