Análise histológica e morfométrica da área cruenta tratada com membrana de silicone: Estudo em ratos

Abstract

BACKGROUND. This study evaluated the effects of a silicone membrane on the treatment of the raw flesh area in wounds. METHODS. The experimental study was carried out with 30 male Wistar rats divided into three groups: in the G G group, the raw area was treated with gauze, in the G H group with homograft, and in the G Sgroup with a silicone membrane. Animals were sacrificed at fourteen days of postoperative. The studied attributes were body mass variation, histological study quantified by morphometric analysis evaluating the number of neovessels, fibroblasts, collagen fibers, leucocytes, monocytes; and using a micrometric ruler measurement of the raw area's thickness. Data were then submitted to statistical analysis. RESULTS. There was no significant difference between the animals' mass (p=0.0685). Predominance of neovessels (p<0.01), fibroblasts (p<0.001) and thickness of the raw flesh were observed in G S animals. There was predominance of leucocytes (p<0.021) and monocytes (p<0.0001) in G H animals. Also, no significant difference between the groups as for collagen fibers (p=0.0536) was observed. CONCLUSION. The silicone membrane promoted granulation tissue with a large number of neovessels, fibroblasts and greater thickness.