The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

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dc.contributor.authorSasahara, Tais H.C.
dc.contributor.authorMachado, Marcia R.F. [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:49:51Z
dc.date.available2019-10-06T15:49:51Z
dc.date.issued2019-01-01
dc.description.abstractStudies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.en
dc.description.affiliationDepartamento de Cirurgia Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade de São Paulo (USP) Cidade Universitária, Avenida Prof. Orlando Marques de Paiva 87
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/n
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/n
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2007/50524-5
dc.format.extent364-370
dc.identifierhttp://dx.doi.org/10.1590/1678-5150-PVB-5808
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019.
dc.identifier.doi10.1590/1678-5150-PVB-5808
dc.identifier.fileS0100-736X2019000500364.pdf
dc.identifier.issn1678-5150
dc.identifier.issn0100-736X
dc.identifier.scieloS0100-736X2019000500364
dc.identifier.scopus2-s2.0-85069048359
dc.identifier.urihttp://hdl.handle.net/11449/187873
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleThe effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphologyen
dc.titleO efeito do 1-metil-4-fenil-1,2,3,6 tetrahidropiridina (MPTP) na morfologia do miocárdio de camundongopt
dc.typeArtigo

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