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Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.

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dc.contributor.authorCarvalho, JCT
dc.contributor.authorSilva, MFC
dc.contributor.authorMaciel, MAM
dc.contributor.authorPinto, Abedala Derbli [UNESP]
dc.contributor.authorNunes, D. S.
dc.contributor.authorLima, R. M.
dc.contributor.authorBastos, J. K.
dc.contributor.authorSarti, S. J.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionFED UNIV PARA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:29:28Z
dc.date.available2014-05-20T15:29:28Z
dc.date.issued1996-10-01
dc.description.abstractThe anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.en
dc.description.affiliationUNIV SAO PAULO,FAC CIENCIAS FARMACEUT RIBEIRAO PRETO,DEPT CIENCIAS FARMACEUT,BR-14014903 RIBEIRAO PRET,SP,BRAZIL
dc.description.affiliationUNIV FED RIO DE JANEIRO,INST QUIM,BR-21910240 RIO JANEIRO,BRAZIL
dc.description.affiliationFED UNIV PARA,DEPT QUIM,CCEN,BR-66075900 BELEM,PARA,BRAZIL
dc.format.extent402-404
dc.identifierhttp://dx.doi.org/10.1055/s-2006-957925
dc.identifier.citationPlanta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.
dc.identifier.doi10.1055/s-2006-957925
dc.identifier.issn0032-0943
dc.identifier.urihttp://hdl.handle.net/11449/39058
dc.identifier.wosWOS:A1996VQ03600004
dc.language.isoeng
dc.publisherGeorg Thieme Verlag
dc.relation.ispartofPlanta Medica
dc.relation.ispartofjcr2.494
dc.relation.ispartofsjr0,581
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCroton cajucarapt
dc.subjectEuphorbiaceaept
dc.subjecttrans-dehydrocrotoninpt
dc.subject19-nor-clerodane diterpenept
dc.subjectanti-inflammatory and antinociceptivept
dc.titleInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.en
dc.typeArtigo
dcterms.licensehttp://www.thieme.com//media/ita/pubid-1019644585.pdf
dcterms.rightsHolderGeorg Thieme Verlag
dspace.entity.typePublication
unesp.author.orcid0000-0001-5256-1422[1]
unesp.author.orcid0000-0003-3662-9794[1]

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