Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019)
dc.contributor.author | Ribeiro, Márcio Garcia [UNESP] | |
dc.contributor.author | de Morais, Amanda Bonalume Cordeiro [UNESP] | |
dc.contributor.author | Alves, Ana Carolina [UNESP] | |
dc.contributor.author | Bolaños, Carmen Alicia Daza | |
dc.contributor.author | de Paula, Carolina Lechinski [UNESP] | |
dc.contributor.author | Portilho, Fábio Vinicius Ramos [UNESP] | |
dc.contributor.author | de Nardi Júnior, Geraldo | |
dc.contributor.author | Lara, Gustavo Henrique Batista [UNESP] | |
dc.contributor.author | de Souza Araújo Martins, Lorrayne [UNESP] | |
dc.contributor.author | Moraes, Lucieny Sierra [UNESP] | |
dc.contributor.author | Risseti, Rafaela Mastrangelo [UNESP] | |
dc.contributor.author | Guerra, Simony Trevizan [UNESP] | |
dc.contributor.author | Bello, Thaís Spessotto [UNESP] | |
dc.contributor.author | Siqueira, Amanda Keller [UNESP] | |
dc.contributor.author | Bertolini, Amanda Bezerra [UNESP] | |
dc.contributor.author | Rodrigues, Carolina Aparecida [UNESP] | |
dc.contributor.author | Paschoal, Natália Rodrigues [UNESP] | |
dc.contributor.author | de Almeida, Beatriz Oliveira [UNESP] | |
dc.contributor.author | Listoni, Fernando José Paganini [UNESP] | |
dc.contributor.author | Sánchez, Luísa Fernanda García [UNESP] | |
dc.contributor.author | Paes, Antonio Carlos [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Antonio Nariño University | |
dc.contributor.institution | FATEC | |
dc.date.accessioned | 2022-05-01T12:09:41Z | |
dc.date.available | 2022-05-01T12:09:41Z | |
dc.date.issued | 2022-03-01 | |
dc.description.abstract | Klebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997–2019). The isolates were obtained from different clinical disorders from dogs (n = 393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n = 22), sheep (n = 5), goats (n = 2), and buffalo (n = 1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 = 12.2%), reproductive (85/697 = 12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 = 16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 = 74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62 = 40.3%), and trimethoprim/sulfamethoxazole (100/252 = 39.7), and multidrug resistance to ≥ 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and ~ 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern. | en |
dc.description.affiliation | Department of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-UNESP, SP | |
dc.description.affiliation | School of Veterinary Medicine and Animal Science São Paulo State University-UNESP, SP | |
dc.description.affiliation | Department of Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences Antonio Nariño University | |
dc.description.affiliation | Technology Faculty FATEC, SP | |
dc.description.affiliationUnesp | Department of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-UNESP, SP | |
dc.description.affiliationUnesp | School of Veterinary Medicine and Animal Science São Paulo State University-UNESP, SP | |
dc.format.extent | 455-464 | |
dc.identifier | http://dx.doi.org/10.1007/s42770-021-00667-0 | |
dc.identifier.citation | Brazilian Journal of Microbiology, v. 53, n. 1, p. 455-464, 2022. | |
dc.identifier.doi | 10.1007/s42770-021-00667-0 | |
dc.identifier.issn | 1678-4405 | |
dc.identifier.issn | 1517-8382 | |
dc.identifier.scopus | 2-s2.0-85122670981 | |
dc.identifier.uri | http://hdl.handle.net/11449/233995 | |
dc.language.iso | eng | |
dc.relation.ispartof | Brazilian Journal of Microbiology | |
dc.source | Scopus | |
dc.subject | Clinical and epidemiological aspects | |
dc.subject | Companion animals | |
dc.subject | Klebsiella pneumoniae | |
dc.subject | Livestock | |
dc.subject | Multidrug-resistant bacteria | |
dc.title | Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019) | en |
dc.type | Artigo | |
unesp.author.orcid | 0000-0003-2682-9389[1] |