Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019)

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dc.contributor.authorRibeiro, Márcio Garcia [UNESP]
dc.contributor.authorde Morais, Amanda Bonalume Cordeiro [UNESP]
dc.contributor.authorAlves, Ana Carolina [UNESP]
dc.contributor.authorBolaños, Carmen Alicia Daza
dc.contributor.authorde Paula, Carolina Lechinski [UNESP]
dc.contributor.authorPortilho, Fábio Vinicius Ramos [UNESP]
dc.contributor.authorde Nardi Júnior, Geraldo
dc.contributor.authorLara, Gustavo Henrique Batista [UNESP]
dc.contributor.authorde Souza Araújo Martins, Lorrayne [UNESP]
dc.contributor.authorMoraes, Lucieny Sierra [UNESP]
dc.contributor.authorRisseti, Rafaela Mastrangelo [UNESP]
dc.contributor.authorGuerra, Simony Trevizan [UNESP]
dc.contributor.authorBello, Thaís Spessotto [UNESP]
dc.contributor.authorSiqueira, Amanda Keller [UNESP]
dc.contributor.authorBertolini, Amanda Bezerra [UNESP]
dc.contributor.authorRodrigues, Carolina Aparecida [UNESP]
dc.contributor.authorPaschoal, Natália Rodrigues [UNESP]
dc.contributor.authorde Almeida, Beatriz Oliveira [UNESP]
dc.contributor.authorListoni, Fernando José Paganini [UNESP]
dc.contributor.authorSánchez, Luísa Fernanda García [UNESP]
dc.contributor.authorPaes, Antonio Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAntonio Nariño University
dc.contributor.institutionFATEC
dc.date.accessioned2022-05-01T12:09:41Z
dc.date.available2022-05-01T12:09:41Z
dc.date.issued2022-03-01
dc.description.abstractKlebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997–2019). The isolates were obtained from different clinical disorders from dogs (n = 393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n = 22), sheep (n = 5), goats (n = 2), and buffalo (n = 1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 = 12.2%), reproductive (85/697 = 12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 = 16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 = 74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62 = 40.3%), and trimethoprim/sulfamethoxazole (100/252 = 39.7), and multidrug resistance to ≥ 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and ~ 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern.en
dc.description.affiliationDepartment of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-UNESP, SP
dc.description.affiliationSchool of Veterinary Medicine and Animal Science São Paulo State University-UNESP, SP
dc.description.affiliationDepartment of Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences Antonio Nariño University
dc.description.affiliationTechnology Faculty FATEC, SP
dc.description.affiliationUnespDepartment of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-UNESP, SP
dc.description.affiliationUnespSchool of Veterinary Medicine and Animal Science São Paulo State University-UNESP, SP
dc.format.extent455-464
dc.identifierhttp://dx.doi.org/10.1007/s42770-021-00667-0
dc.identifier.citationBrazilian Journal of Microbiology, v. 53, n. 1, p. 455-464, 2022.
dc.identifier.doi10.1007/s42770-021-00667-0
dc.identifier.issn1678-4405
dc.identifier.issn1517-8382
dc.identifier.scopus2-s2.0-85122670981
dc.identifier.urihttp://hdl.handle.net/11449/233995
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Microbiology
dc.sourceScopus
dc.subjectClinical and epidemiological aspects
dc.subjectCompanion animals
dc.subjectKlebsiella pneumoniae
dc.subjectLivestock
dc.subjectMultidrug-resistant bacteria
dc.titleKlebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019)en
dc.typeArtigo
unesp.author.orcid0000-0003-2682-9389[1]

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