Mycobacterium branderi Infection in a Horse with Granulomatous Mesenteric Lymphadenitis

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dc.contributor.authorSilva, F. S.
dc.contributor.authorLorenzett, M. P.
dc.contributor.authorBianchi, M.
dc.contributor.authorBastos, H. B. A.
dc.contributor.authorLarentis, G. R.
dc.contributor.authorPaul, L. G.
dc.contributor.authorSnel, G. G. M.
dc.contributor.authorOliveira-Filho, J. P. [UNESP]
dc.contributor.authorMattos, R. C.
dc.contributor.authorSonne, L.
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-04T12:37:55Z
dc.date.available2019-10-04T12:37:55Z
dc.date.issued2019-04-01
dc.description.abstractAlthough relatively uncommon in horses, infections caused by Mycobacterium spp. may affect the gastrointes-tinal tract. Mycobacterium branderi is a non-tuberculous Mycobacterium (NTM) that causes respiratory infections in man. Non-tuberculous mycobacteria may also affect horses; however, infection by M. branderi has not yet been reported in this species. This report describes the clinical, pathological, microbiological and molecular findings of M. branderi infection in a horse, causing granulomatous mesenteric lymphadenitis. A 17-year-old Thoroughbred stallion had a 3-month history of chronic diarrhoea, cachexia and ventral and cervical oedema. Necropsy examination revealed severe mesenteric lymphadenomegaly, together with mesenteric lymphangiectasia and diffuse small intestinal mucosal thickening. Microscopically, the mesenteric lymph node had diffuse granulomatous inflammatory infiltration, replacing most of the nodal parenchyma, with multiple acid-fast bacilli within the cytoplasm of macrophages. There was also diffuse lymphangiectasia. Fresh samples of mesenteric lymph nodes yielded no bacterial growth; however, nested polymerase chain reaction products obtained from the mesenteric lymph node samples were consistent with M. branderi. This infection should be included as a differential diagnosis in cases of chronic diarrhoea in horses, especially when granulomatous enteritis and lymphadenitis are also observed. (C) 2019 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Vet Pathol, Av Bento Goncalves, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Anim Reprod, Av Bento Goncalves, Porto Alegre, RS, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent30-34
dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2019.03.003
dc.identifier.citationJournal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 168, p. 30-34, 2019.
dc.identifier.doi10.1016/j.jcpa.2019.03.003
dc.identifier.issn0021-9975
dc.identifier.urihttp://hdl.handle.net/11449/185713
dc.identifier.wosWOS:000467917700007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Comparative Pathology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecthorse
dc.subjectmycobacterial infection
dc.subjectMycobacterium branderi
dc.subjectnon-tuberculous mycobacteria
dc.titleMycobacterium branderi Infection in a Horse with Granulomatous Mesenteric Lymphadenitisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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