New complexes of light lanthanides with the valsartan in the solid state: Thermal and spectroscopic studies

dc.contributor.authorEkawa, Bruno [UNESP]
dc.contributor.authorGoncalves Nunes, Wilhan Donizete [UNESP]
dc.contributor.authorTeixeira, Jose Augusto [UNESP]
dc.contributor.authorCebim, Marco Aurelio [UNESP]
dc.contributor.authorIonashiro, Elias Yuki
dc.contributor.authorCaires, Flavio Junior [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2019-10-03T18:19:47Z
dc.date.available2019-10-03T18:19:47Z
dc.date.issued2018-10-01
dc.description.abstractNew lanthanides complexes with valsartan drug (H(2)Val) with stoichiometry Ln(2)(Val)(3)center dot nH(2)O (Ln = La, Ce, Pr, Nd and Sm) were obtained by reacting a solution of the lanthanide nitrate with a solution of valsartan sodium salt. The complexes were characterized by simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC) in dry air and nitrogen atmospheres, Evolved gas analysis (EGA) by TG-DSC-FTIR, Elemental Analysis (EA), complexometry with EDTA, Fourier transform Infrared and Raman (FTIR and FT-Raman) spectroscopy, UV vis spectroscopy and Powder X-Ray Diffraction (PXRD). The thermal decomposition of the complexes differed in dry air atmosphere with four steps for Ce, five for La and Pr and six for Nd and Sm. In nitrogen atmosphere all the complexes had a similar behavior, with three mass loss steps up to 1000 degrees C, leading to the formation of a mixture of carbonized material and metal oxide. The main gaseous products released during the thermal decomposition of these compounds were nitrous oxide, carbon dioxide and carbon monoxide (in air atmosphere), ammonia, nitrous oxide, carbon dioxide, carbon monoxide, and an unsaturated ketone or a mixture of unsaturated hydrocarbon and a ketone (in nitrogen atmosphere). The PXRD data suggest that the compounds are amorphous; the FTIR spectra suggests coordination of the ligand by the tetrazole ring, and by the carboxylate group as monodentate ligand; finally, the UV-vis spectra of the Pr, Nd and Sm complexes provided information about the degree of covalence of each compound.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, CP 355, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Goias, Inst Quim, Campus Samambaia, BR-74690900 Goiania, Go, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias, BR-17033260 Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, CP 355, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias, BR-17033260 Bauru, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2017/14936-9
dc.description.sponsorshipIdFAPESP: 2018/12463-9
dc.description.sponsorshipIdCNPq: 421469/2016-1
dc.format.extent299-309
dc.identifierhttp://dx.doi.org/10.1016/j.jaap.2018.08.023
dc.identifier.citationJournal Of Analytical And Applied Pyrolysis. Amsterdam: Elsevier Science Bv, v. 135, p. 299-309, 2018.
dc.identifier.doi10.1016/j.jaap.2018.08.023
dc.identifier.issn0165-2370
dc.identifier.lattes2034352556339501
dc.identifier.urihttp://hdl.handle.net/11449/184089
dc.identifier.wosWOS:000449125700034
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Analytical And Applied Pyrolysis
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLight lanthanides
dc.subjectValsartan
dc.subjectThermal behavior
dc.subjectPyrolysis
dc.subjectEvolved gas analysis
dc.titleNew complexes of light lanthanides with the valsartan in the solid state: Thermal and spectroscopic studiesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2034352556339501
unesp.author.orcid0000-0003-2326-241X[1]
unesp.author.orcid0000-0002-6557-9557[3]

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