Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency

Página do item simplificado
dc.contributor.authorCanton-Martínez, Ermilo
dc.contributor.authorRentería, Iván
dc.contributor.authorGarcía-Suárez, Patricia C.
dc.contributor.authorMoncada-Jiménez, José
dc.contributor.authorMachado-Parra, Juan Pablo
dc.contributor.authorLira, Fabio Santos [UNESP]
dc.contributor.authorJohnson, David K.
dc.contributor.authorJiménez-Maldonado, Alberto
dc.contributor.institutionUniversidad Autónoma de Baja California
dc.contributor.institutionUniversity of Kansas
dc.contributor.institutionUniversity of Costa Rica
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionDavis
dc.date.accessioned2022-04-28T19:52:46Z
dc.date.available2022-04-28T19:52:46Z
dc.date.issued2022-03-07
dc.description.abstractBackground: Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults. Methods: Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m2) completed either a three times/week (3-t/w) (n = 8) or five times/week (5-t/w) (n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program. Results: Regardless of the group, the serum BDNF increased following the intervention (p < 0.001), and there were no significant group (p = 0.827) or interaction (p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p = 0.007), with a non-significant group (p = 0.722) or interaction (p = 0.223) effects. Upper- and lower-body strength increased in both groups (p = 0.003); however, there was no effect of the training frequency (p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p = 0.053). Finally, the body fat percentage was unchanged. Conclusion: Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults.en
dc.description.affiliationFacultad de Deportes Universidad Autónoma de Baja California
dc.description.affiliationDepartment of Health Sports and Exercise Sciences University of Kansas
dc.description.affiliationHuman Movement Sciences Research Center (CIMOHU) University of Costa Rica
dc.description.affiliationExercise and Immunometabolism Research Group Department of Physical Education Paulista State University UNESP
dc.description.affiliationDepartment of Neurology University of California Davis
dc.description.affiliationUnespExercise and Immunometabolism Research Group Department of Physical Education Paulista State University UNESP
dc.identifierhttp://dx.doi.org/10.3389/fnagi.2022.791698
dc.identifier.citationFrontiers in Aging Neuroscience, v. 14.
dc.identifier.doi10.3389/fnagi.2022.791698
dc.identifier.issn1663-4365
dc.identifier.scopus2-s2.0-85127265387
dc.identifier.urihttp://hdl.handle.net/11449/223729
dc.language.isoeng
dc.relation.ispartofFrontiers in Aging Neuroscience
dc.sourceScopus
dc.subjectbody fat
dc.subjectbrain derived neurotrophic factor
dc.subjectconcurrent training
dc.subjectelderly
dc.subjectheart rate
dc.titleConcurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequencyen
dc.typeArtigo

Arquivos

Coleções

Artigos