Importância da linha de base pré-exposição das colinesterases (ChEs) no controle ocupacional a praguicidas organofosforados e carbamatos

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2005-06-01

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The most immediate toxic effects of a poisoning for organophosphate or carbamate are promoted by inhibition of cholinesterases (ChEs). However, a serious limitation to the diagnosis of mild organophosphate or carbamate poisoning and to preventive screening of organophosphate-exposed workers has been the large interindividual variability in ChEs activity. This makes it necessary to obtain a pre-exposure baseline measurement of enzyme activity as a basis for evaluating subsequent declines. Thus, the objective of this work is demonstrate the value of the pre-exposure baseline in the interpretation of the results of the ChEs activity of the carbamate or organophosphate-exposed workers. Using Nabb & Whitfield (1967) method to analyze blood of 48 workers the results have shown a erythrocyte cholinesterase range of 10.1 to 19.7 μmol/min/mL and plasm cholinesterase range of 2.2 to 6.9 μmol/min/mL. Despite the large interindividual variation presented, when one used the pre-exposure baseline it was possible to correlate symptoms of light poisoning of the exposure workers to carbamate with fall in the Er-ChE activity lesser then 30% of the pre-exposure baseline activity.

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Cholinesterases, Organophosphate, occupational exposure, baseline, carbamic acid, cholinesterase, organophosphate, pesticide, blood analysis, conference paper, correlation analysis, diagnostic value, enzyme activity, erythrocyte, human, intoxication, occupational exposure, occupational toxicology, symptom

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Revista Brasileira de Toxicologia, v. 18, n. 1, p. 43-48, 2005.