Effect of Using Different Vehicles on the Physicochemical, Antimicrobial, and Biological Properties of White Mineral Trioxide Aggregate

dc.contributor.authorCavenago, Bruno Cavalini
dc.contributor.authordel Carpio-Perochena, Aldo Enrique
dc.contributor.authorOrdinola-Zapata, Ronald
dc.contributor.authorEstrela, Carlos
dc.contributor.authorGarlet, Gustavo Pompermaier
dc.contributor.authorTanomaru-Filho, Mario [UNESP]
dc.contributor.authorWeckwerth, Paulo Henrique
dc.contributor.authorAndrade, Flaviana Bombarda de
dc.contributor.authorHungaro Duarte, Marco Antonio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSagrado Coracao Univ
dc.description.abstractIntroduction: This study evaluated the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate (MTA) mixed with aqueous and propylene glycol extracts of Arctium lappa L. and Casearia sylvestris Sw. Methods: The setting time test was performed according to American Society for Testing and Materials 266/2008 and flowability by American National Standards Institute/American Dental Association 57/2012 standard specifications. The following parameters were assessed: volumetric change by micro computed tomography; pH level and calcium ion release measured after 3 hours and 1, 3, 7, and 15 days; antimicrobial effect by the dentin decontamination method with intratubular Enterococcus faecalis viability, verified by using confocal laser scanning microscopy; and biocompatibility by histologic-morphometric analyses of inflammatory infiltrate at subcutaneous implant sites after 15, 30, and 60 days. In addition, rat alveolar tissues with implants were processed to measure tumor necrosis factor-alpha and interleukin-10 cytokines by enzyme-linked immunosorbent assay. Results: The plant extracts associated with MTA significantly increased the final setting time; however, they did not influence volumetric change (P > .05) and maintained medium alkalinity and calcium ion release. Propylene glycol extracts showed higher flowability. Casearia sylvestris increased the cementing effect against E. faecalis after 24-hour and 168-hour periods. Histologic evaluation of inflammatory infiltrate showed no significant differences between plant extracts groups and the distilled water group for all periods. Tumor necrosis factor-alpha and interleukin-10 expression was similar among groups (P > .05). Conclusions: Casearia sylvestris extracts increased the antimicrobial effect of MTA and did not influence biocompatibility but changed some physicochemical properties.en
dc.description.affiliationUniv Sao Paulo, Sch Dent Bauru, Dept Operat Dent Endodont & Dent Mat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Dept Restorat Dent, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Goias, Dept Stomatol Sci, Goiania, Go, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Dent Bauru, Dept Biol Sci, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Restorat Dent, Araraquara Dent Sch, Sao Paulo, Brazil
dc.description.affiliationSagrado Coracao Univ, Ctr Hlth Sci, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Restorat Dent, Araraquara Dent Sch, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2011/18272-1
dc.identifier.citationJournal Of Endodontics. New York: Elsevier Science Inc, v. 43, n. 5, p. 779-786, 2017.
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Endodontics
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEnterococcus faecalis
dc.subjectmaterial testing
dc.titleEffect of Using Different Vehicles on the Physicochemical, Antimicrobial, and Biological Properties of White Mineral Trioxide Aggregateen
dcterms.rightsHolderElsevier B.V.


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